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引用次数: 0
摘要
在哺乳动物中,卵母细胞的生成在出生前就开始了,并在减数分裂原期I的二分裂阶段暂停,直到黄体生成素(LH)激增,恢复减数分裂。卵母细胞成熟是指减数分裂的恢复,它引导卵母细胞从减数分裂原期 I 进入分裂后期 II。这一过程需要精心调节,以确保正常排卵和成功受精。环境毒物会产生过量的氧化应激,从而破坏卵母细胞的成熟。在本综述中,我们对这些诱发线粒体功能障碍和纺锤体形成异常的环境毒物进行了分类。此外,我们还讨论了阻碍卵母细胞成熟的潜在机制,包括线粒体功能、纺锤体形成和 DNA 损伤反应。
How Do Environmental Toxicants Affect Oocyte Maturation Via Oxidative Stress?
In mammals, oogenesis initiates before birth and pauses at the dictyate stage of meiotic prophase I until luteinizing hormone (LH) surges to resume meiosis. Oocyte maturation refers to the resumption of meiosis that directs oocytes to advance from prophase I to metaphase II of meiosis. This process is carefully modulated to ensure a normal ovulation and successful fertilization. By generating excessive amounts of oxidative stress, environmental toxicants can disrupt the oocyte maturation. In this review, we categorized these environmental toxicants that induce mitochondrial dysfunction and abnormal spindle formation. Further, we discussed the underlying mechanisms that hinder oocyte maturation, including mitochondrial function, spindle formation, and DNA damage response.
期刊介绍:
"Advances in Anatomy, Embryology and Cell Biology" presents critical reviews on all topical fields of normal and experimental anatomy including cell biology. The multi-perspective presentation of morphological aspects of basic biological phenomen in the human constitutes the main focus of the series. The contributions re-evaluate the latest findings and show ways for further research.