利用材料解决方案设计细菌疗法。

IF 14.3 1区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Trends in biotechnology Pub Date : 2024-07-18 DOI:10.1016/j.tibtech.2024.06.011

Sourik Dey, Shrikrishnan Sankaran

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引用次数: 0

摘要

工程细菌疗法的最新进展凸显了它们通过有针对性的活体干预治疗疾病的潜力。尽管它们在早期临床阶段的表现很有希望，但目前还没有工程治疗细菌获得批准，这主要是由于在证明疗效的同时确保生物安全所面临的挑战。材料科学的创新，特别是将细菌封装在水凝胶中，为提高细菌在治疗应用中的存活率、疗效和安全性提供了一条大有可为的途径。本综述将讨论这种开发活体治疗材料的跨学科方法。水凝胶不仅能保护细菌免受恶劣生理条件的影响，还能控制治疗药物的释放，防止细菌意外扩散。封装材料的战略性使用可以重新定义工程细菌疗法的传递和功能，促进其临床转化。

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Engineered bacterial therapeutics with material solutions.

Recent advances in engineered bacterial therapeutics underscore their potential in treating diseases via targeted, live interventions. Despite their promising performance in early clinical phases, no engineered therapeutic bacteria have yet received approval, primarily due to challenges in proving efficacy while ensuring biosafety. Material science innovations, particularly the encapsulation of bacteria within hydrogels, present a promising avenue to enhance bacterial survival, efficacy, and safety in therapeutic applications. This review discusses this interdisciplinary approach to develop living therapeutic materials. Hydrogels not only safeguard the bacteria from harsh physiological conditions but also enable controlled therapeutic release and prevent unintended bacterial dissemination. The strategic use of encapsulation materials could redefine the delivery and functionality of engineered bacterial therapeutics, facilitating their clinical translation.

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来源期刊

Trends in biotechnology 工程技术-生物工程与应用微生物

CiteScore

28.60

自引率

1.20%

发文量

198

审稿时长

1 months

期刊介绍： Trends in Biotechnology publishes reviews and perspectives on the applied biological sciences, focusing on useful science applied to, derived from, or inspired by living systems. The major themes that TIBTECH is interested in include: Bioprocessing (biochemical engineering, applied enzymology, industrial biotechnology, biofuels, metabolic engineering) Omics (genome editing, single-cell technologies, bioinformatics, synthetic biology) Materials and devices (bionanotechnology, biomaterials, diagnostics/imaging/detection, soft robotics, biosensors/bioelectronics) Therapeutics (biofabrication, stem cells, tissue engineering and regenerative medicine, antibodies and other protein drugs, drug delivery) Agroenvironment (environmental engineering, bioremediation, genetically modified crops, sustainable development).