Joanna M Schaenman, Stephen Samuel Weigt, Mengtong Pan, Joshua J Lee, Xinkai Zhou, David Elashoff, Michael Y Shino, John M Reynolds, Marie Budev, Pali Shah, Lianne G Singer, Jamie L Todd, Laurie D Snyder, Scott Palmer, John Belperio
{"title":"肺移植前 Th2 免疫反应循环指标的改变与原发性移植物功能障碍的减少有关。","authors":"Joanna M Schaenman, Stephen Samuel Weigt, Mengtong Pan, Joshua J Lee, Xinkai Zhou, David Elashoff, Michael Y Shino, John M Reynolds, Marie Budev, Pali Shah, Lianne G Singer, Jamie L Todd, Laurie D Snyder, Scott Palmer, John Belperio","doi":"10.1016/j.healun.2024.07.011","DOIUrl":null,"url":null,"abstract":"<p><p>Primary graft dysfunction (PGD) is a complication of lung transplantation that continues to cause significant morbidity. The Th2 immune response has been shown to counteract tissue-damaging inflammation. We hypothesized that Th2 cytokines/chemokines in blood would be associated with protection from PGD. Utilizing pretransplant sera from the multicenter clinical trials in organ transplantation study, we evaluated Th2 cytokines/chemokines in 211 patients. Increased concentrations of Th2 cytokines were associated with freedom from PGD, namely IL-4 (odds ratio [OR] 0.66 [95% confidence interval {CI} 0.45-0.99], p = 0.043), IL-9 (OR 0.68 [95% CI 0.49-0.94], p = 0.019), IL-13 (OR 0.73 [95% CI 0.55-0.96], p = 0.023), and IL-6 (OR 0.74 [95% CI 0.56-0.98], p = 0.036). Multivariable regression performed for each cytokine, including clinically relevant covariables, confirmed these associations and additionally demonstrated association with IL-5 (OR 0.57 [95% CI 0.36-0.89], p = 0.014) and IL-10 (OR 0.55 [95% CI 0.32-0.96], p = 0.035). Higher levels of Th2 immune response before lung transplant appear to have a protective effect against PGD, which parallels the Th2 role in resolving inflammation and tissue injury. Pretransplant cytokine assessments could be utilized for recipient risk stratification.</p>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":null,"pages":null},"PeriodicalIF":6.4000,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Alterations in circulating measures of Th2 immune responses pre-lung transplant associates with reduced primary graft dysfunction.\",\"authors\":\"Joanna M Schaenman, Stephen Samuel Weigt, Mengtong Pan, Joshua J Lee, Xinkai Zhou, David Elashoff, Michael Y Shino, John M Reynolds, Marie Budev, Pali Shah, Lianne G Singer, Jamie L Todd, Laurie D Snyder, Scott Palmer, John Belperio\",\"doi\":\"10.1016/j.healun.2024.07.011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Primary graft dysfunction (PGD) is a complication of lung transplantation that continues to cause significant morbidity. The Th2 immune response has been shown to counteract tissue-damaging inflammation. We hypothesized that Th2 cytokines/chemokines in blood would be associated with protection from PGD. Utilizing pretransplant sera from the multicenter clinical trials in organ transplantation study, we evaluated Th2 cytokines/chemokines in 211 patients. Increased concentrations of Th2 cytokines were associated with freedom from PGD, namely IL-4 (odds ratio [OR] 0.66 [95% confidence interval {CI} 0.45-0.99], p = 0.043), IL-9 (OR 0.68 [95% CI 0.49-0.94], p = 0.019), IL-13 (OR 0.73 [95% CI 0.55-0.96], p = 0.023), and IL-6 (OR 0.74 [95% CI 0.56-0.98], p = 0.036). Multivariable regression performed for each cytokine, including clinically relevant covariables, confirmed these associations and additionally demonstrated association with IL-5 (OR 0.57 [95% CI 0.36-0.89], p = 0.014) and IL-10 (OR 0.55 [95% CI 0.32-0.96], p = 0.035). Higher levels of Th2 immune response before lung transplant appear to have a protective effect against PGD, which parallels the Th2 role in resolving inflammation and tissue injury. Pretransplant cytokine assessments could be utilized for recipient risk stratification.</p>\",\"PeriodicalId\":15900,\"journal\":{\"name\":\"Journal of Heart and Lung Transplantation\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":6.4000,\"publicationDate\":\"2024-07-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Heart and Lung Transplantation\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.healun.2024.07.011\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Heart and Lung Transplantation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.healun.2024.07.011","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
摘要
原发性移植物功能障碍(PGD)是肺移植的一种并发症,会继续导致严重的发病率。Th2 免疫反应已被证明能抵消组织损伤性炎症。我们假设血液中的 Th2 细胞因子/凝血因子与防止 PGD 有关。利用多中心器官移植临床试验(CTOT-20)研究中的移植前血清,我们对 211 名患者的 Th2 细胞因子/造血因子进行了评估。Th2细胞因子浓度升高与免于PGD有关,即IL-4(Odds Ratio (OR) 0.66 (95% CI 0.45-0.99),p=0.043)、IL-9(OR 0.68 (95% CI 0.49-0.94),p=0.019)、IL-13(OR 0.73 (95% CI 0.55-0.96),p=0.023)和IL-6(OR 0.74 (95% CI 0.56-0.98),p=0.036)。对包括临床相关协变量在内的每种细胞因子进行的多变量回归证实了这些相关性,此外还显示与 IL-5(OR 0.57(95% CI 0.36-0.89),p=0.014)和 IL-10(OR 0.55(95% CI 0.32-0.96),p=0.035)相关。肺移植前较高水平的 Th2 免疫反应似乎对 PGD 有保护作用,这与 Th2 在消除炎症和组织损伤中的作用相似。移植前细胞因子评估可用于受者风险分层。
Alterations in circulating measures of Th2 immune responses pre-lung transplant associates with reduced primary graft dysfunction.
Primary graft dysfunction (PGD) is a complication of lung transplantation that continues to cause significant morbidity. The Th2 immune response has been shown to counteract tissue-damaging inflammation. We hypothesized that Th2 cytokines/chemokines in blood would be associated with protection from PGD. Utilizing pretransplant sera from the multicenter clinical trials in organ transplantation study, we evaluated Th2 cytokines/chemokines in 211 patients. Increased concentrations of Th2 cytokines were associated with freedom from PGD, namely IL-4 (odds ratio [OR] 0.66 [95% confidence interval {CI} 0.45-0.99], p = 0.043), IL-9 (OR 0.68 [95% CI 0.49-0.94], p = 0.019), IL-13 (OR 0.73 [95% CI 0.55-0.96], p = 0.023), and IL-6 (OR 0.74 [95% CI 0.56-0.98], p = 0.036). Multivariable regression performed for each cytokine, including clinically relevant covariables, confirmed these associations and additionally demonstrated association with IL-5 (OR 0.57 [95% CI 0.36-0.89], p = 0.014) and IL-10 (OR 0.55 [95% CI 0.32-0.96], p = 0.035). Higher levels of Th2 immune response before lung transplant appear to have a protective effect against PGD, which parallels the Th2 role in resolving inflammation and tissue injury. Pretransplant cytokine assessments could be utilized for recipient risk stratification.
期刊介绍:
The Journal of Heart and Lung Transplantation, the official publication of the International Society for Heart and Lung Transplantation, brings readers essential scholarly and timely information in the field of cardio-pulmonary transplantation, mechanical and biological support of the failing heart, advanced lung disease (including pulmonary vascular disease) and cell replacement therapy. Importantly, the journal also serves as a medium of communication of pre-clinical sciences in all these rapidly expanding areas.