甲状腺发育不良与山羊侏儒症、骨质疏松症和自发性骨折有关。

IF 0.8 4区 农林科学 Q4 PATHOLOGY
Felipe M. Pastor, Camila I. Amaral, Natália de Melo Ocarino, Lucas A. Dias, Andressa B. da Silveira Xavier, Eloá C. Castelo Branco, Rogéria Serakides
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引用次数: 0

摘要

米纳斯吉拉斯联邦大学兽医院接诊了一只 11 个月大的雌性萨能山羊,体重 12.7 千克,原因是胸骨后仰。经临床检查,这只山羊比预期的要小得多,身上的毛发与小狗相似,头部、颈背和胸背颅骨部位有色素沉着。影像学检查显示,它的两个股骨都有骨折,全身骨质严重疏松。鉴于预后不良,该动物被安乐死。尸体解剖显示,动物全身苍白,骨盆四肢肌肉萎缩,皮下脂肪组织储备很少。两根股骨都有完全闭合性骨骺骨折。第二腰椎因骨折导致长度严重缩短,椎体向椎管背侧移位,脊髓受到压迫。长骨和椎骨的皮质严重变薄,髓质管扩大,阻力减小。甲状腺不在正常解剖位置。气管中三分之一处靠近胸腔入口的浆膜上有一个淡红色结节(1.0 × 0.4 厘米),经确认为异位甲状腺组织。显微镜下,骨骼有生长停滞和严重骨质疏松的迹象。异位甲状腺结节增生,滤泡细胞严重肥大。脊髓受到脊椎骨折的压迫,并有局部广泛和严重的髓鞘缺损。根据病理特征,该病例被诊断为甲状腺发育不良,其特点是异位甲状腺缺失和异位甲状腺组织,伴有骨生长中断、侏儒症、骨质疏松症和自发性继发性骨折并压迫腰椎脊髓。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Thyroid dysgenesis associated with dwarfism, osteoporosis and spontaneous fractures in a goat

An 11-month-old female Saanen goat, weighing 12.7 kg, was taken to the Veterinary Hospital of the Federal University of Minas Gerais because of sternal recumbency. On clinical examination, the animal was much smaller than expected and had hair similar to that of puppies and areas of hyperpigmentation on the head and dorsocervical and dorsothoracic cranial regions. Radiographic examination revealed fractures in both femurs and severe generalized osteoporosis. Given the unfavourable prognosis, the animal was euthanized. Necropsy revealed generalized pallor, muscular atrophy of the pelvic limbs and little reserve of subcutaneous adipose tissue. Both femurs had complete and closed diaphyseal fractures. The second lumbar vertebra was severely reduced in length as a result of a fracture, with dorsal displacement of the vertebral body towards the vertebral canal and compression of the spinal cord. Long bones and vertebrae had severe cortical thinning, enlargement of the medullary canal and reduced resistance. The thyroid gland was not in its normal anatomical location. A pale red nodule (1.0 × 0.4 cm) in the serosa of the middle third of the trachea, close to the thoracic entrance, was confirmed as ectopic thyroid tissue. Microscopically, the bones had evidence of growth arrest and severe osteoporosis. The ectopic thyroid nodule was hyperplastic with severe hypertrophy of follicular cells. The spinal cord was compressed by vertebral fractures and had focally extensive and severe myelomalacia. Based on the pathological features, the case was diagnosed as thyroid dysgenesis characterized by eutopic thyroid agenesis and ectopic thyroid tissue, associated with interruption of bone growth with dwarfism, osteoporosis and spontaneous secondary fractures with compression of the lumbar spinal cord.

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来源期刊
CiteScore
1.60
自引率
0.00%
发文量
208
审稿时长
50 days
期刊介绍: The Journal of Comparative Pathology is an International, English language, peer-reviewed journal which publishes full length articles, short papers and review articles of high scientific quality on all aspects of the pathology of the diseases of domesticated and other vertebrate animals. Articles on human diseases are also included if they present features of special interest when viewed against the general background of vertebrate pathology.
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