从移植的骨髓单核细胞向海马神经干细胞直接转移水溶性分子。

Stem cells and development Pub Date : 2024-09-01 Epub Date: 2024-08-09 DOI:10.1089/scd.2024.0043
Yuka Okinaka, Mitsuyo Maeda, Yosky Kataoka, Takayuki Nakagomi, Akiko Doi, Johannes Boltze, Carsten Claussen, Sheraz Gul, Akihiko Taguchi
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引用次数: 0

摘要

血管内移植的骨髓细胞,包括骨髓单核细胞(BM-MNC)和间充质干细胞,可通过间隙连接将水溶性分子转移到大脑内皮细胞。BM-MNC 移植后,可促进海马神经发生,增强神经元功能。在此,我们报告了移植的 BM-MNC 对大脑神经干细胞(NSC)的影响。令人惊讶的是,在细胞移植后10分钟,就观察到水溶性分子从移植的BM-MNC和外周单核细胞直接转移到海马的神经干细胞,还观察到BM-MNC转移到GFAP阳性的皮层星形胶质细胞。体外研究显示,BM-MNC 可抑制 HIF1α 在星形胶质细胞中的表达。我们认为,水溶性分子在循环中的细胞和大脑中的 NSC 之间的短暂直接转移可能是大脑功能修复的生物机制之一。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Direct Water-Soluble Molecules Transfer from Transplanted Bone Marrow Mononuclear Cell to Hippocampal Neural Stem Cells.

Intravascularly transplanted bone marrow cells, including bone marrow mononuclear cells (BM-MNC) and mesenchymal stem cells, transfer water-soluble molecules to cerebral endothelial cells via gap junctions. After transplantation of BM-MNC, this fosters hippocampal neurogenesis and enhancement of neuronal function. Herein, we report the impact of transplanted BM-MNC on neural stem cells (NSC) in the brain. Surprisingly, direct transfer of water-soluble molecules from transplanted BM-MNC and peripheral mononuclear cells to NSC in the hippocampus was observed already 10 min after cell transplantation, and transfer from BM-MNC to GFAP-positive cortical astrocytes was also observed. In vitro investigations revealed that BM-MNC abolish the expression of hypoxia-inducible factor-1α in astrocytes. We suggest that the transient and direct transfer of water-soluble molecules between cells in circulation and NSC in the brain may be one of the biological mechanisms underlying the repair of brain function.

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