甲襞毛细血管镜在硬皮病谱系疾病中的实用性:一项单中心观察性研究。

IF 1.4 4区 医学 Q3 ALLERGY
Postepy Dermatologii I Alergologii Pub Date : 2024-06-01 Epub Date: 2024-06-30 DOI:10.5114/ada.2024.141158
Katarzyna Wiąk-Walerowicz, Ewa Wielosz, Maria Majdan
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引用次数: 0

摘要

简介甲襞毛细血管镜检查是一种评估甲襞微循环的非侵入性方法。这种检查尤其适用于系统性硬皮病和硬皮病系列疾病(即:皮肌炎、多发性肌炎、混合结缔组织病和未分化型硬皮病)的诊断、活动性评估、治疗反应评估以及微血管变化与器官变化的相关性评估。目的:对硬皮病系列疾病患者的病变进行毛细血管镜分析,并确定毛细血管镜图像与器官表现和血清学特征的相关性:研究涉及15名硬皮病谱系疾病患者:结果:8名患者被诊断为混合型系统性结缔组织病,7名患者被诊断为皮肌炎。研究评估了间质性肺病或关节炎等临床症状的出现频率以及 ANA 抗体的存在情况。47%的硬皮病谱系障碍患者被诊断出患有硬皮病样微血管病变。混合型系统性结缔组织疾病患者的病变模式为早期模式,而皮肌炎患者的病变模式为晚期模式。27%的患者出现非特异性变化,27%的患者图像正常:分析还显示,血管数量的减少与间质性肺病的发生有关,而且从统计学角度看,雷诺现象和关节炎在全身结缔组织病患者中的发生率明显高于皮肌炎患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The usefulness of nailfold capillaroscopy in scleroderma-spectrum disorders: a single-centre observational study.

Introduction: Nail-fold capillaroscopy is a non-invasive method for assessment of the microcirculation in nail folds. This examination is particularly useful for diagnosis, assessment of activity, evaluation of the response to treatment, and assessment of the correlation of changes in microvessels with changes in organs in systemic sclerosis and in scleroderma-spectrum diseases, i.e. dermatomyositis, polymyositis, mixed connective tissue disease, and undifferentiated connective tissue disease.

Aim: To perform capillaroscopic analyses of lesions in patients with scleroderma-spectrum diseases and determine the correlation of the capillaroscopic image with organ manifestations and the serological profile.

Material and methods: The study involved 15 patients with scleroderma-spectrum disorders.

Results: Mixed systemic connective tissue disease was diagnosed in 8 patients, and dermatomyositis was detected in 7 patients. The study assessed the frequency of clinical symptoms, e.g. interstitial lung disease or arthritis, and the presence of ANA antibodies. Scleroderma-like microangiopathy was diagnosed in 47% of patients with scleroderma-spectrum disorders. The early pattern was found in patients with mixed systemic connective tissue disease, whereas dermatomyositis was characterized by the late pattern. Non-specific changes were found in 27% of the patients, and a normal image was observed in 27% of the patients.

Conclusions: The analysis also revealed that the reduced number of vessels correlated with the occurrence of interstitial lung disease, and the incidence of Raynaud's phenomenon and arthritis was statistically significantly higher in patients with systemic connective tissue disease than in those with dermatomyositis.

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来源期刊
CiteScore
2.60
自引率
7.10%
发文量
107
审稿时长
6-12 weeks
期刊介绍: Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii is a bimonthly aimed at allergologists and dermatologists.
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