异体骨基质在临床骨科中的应用。

IF 2.4 4区 医学 Q4 CELL & TISSUE ENGINEERING
Regenerative medicine Pub Date : 2024-05-03 Epub Date: 2024-07-19 DOI:10.1080/17460751.2024.2353473
Shaan Manawar, Erica Myrick, Peter Awad, Victor Hung, Cassidy Hinton, Keith Kenter, Karen Bovid, Yong Li
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引用次数: 0

摘要

临床骨科一直致力于改进骨形成的方法。需要进行骨形成的临床应用包括骨科创伤或肿瘤患者的关键性长骨缺损。虽然一些生物材料与自体干细胞结合可显著改善骨修复,但临界大小的损伤仍面临生物材料的适当植入和供体细胞存活的挑战。细胞外基质(ECM)是组织的基本结构,可筑巢和滋养驻留细胞,并支持组织类型的特定功能。ECM 还在细胞信号传递中发挥作用,促进骨骼生长、愈合和新陈代谢。近十年来,人们广泛研究了骨源性 ECM 或类似 ECM 的生物材料的使用,包括脱细胞和脱矿物质骨 ECM。在这篇文章中,我们回顾了脱细胞和去矿物质骨基质目前的生产和应用情况。我们还介绍了目前对全肢脱细胞和再细胞化的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Use of allograft bone matrix in clinical orthopedics.

Clinical orthopedics continuously aims to improve methods for bone formation. Clinical applications where bone formation is necessary include critical long bone defects in orthopedic trauma or tumor patients. Though some biomaterials combined with autologous stem cells significantly improve bone repair, critical-size damages are still challenged with the suitable implantation of biomaterials and donor cell survival. Extracellular matrix (ECM) is the fundamental structure in tissues that can nest and nourish resident cells as well as support specific functions of the tissue type. ECM also plays a role in cell signaling to promote bone growth, healing and turnover. In the last decade, the use of bone-derived ECMs or ECM-similar biomaterials have been widely investigated, including decellularized and demineralized bone ECM. In this article, we reviewed the current productions and applications of decellularized and demineralized bone matrices. We also introduce the current study of whole limb decellularization and recellularization.

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来源期刊
Regenerative medicine
Regenerative medicine 医学-工程:生物医学
CiteScore
4.20
自引率
3.70%
发文量
82
审稿时长
6-12 weeks
期刊介绍: Regenerative medicine replaces or regenerates human cells, tissue or organs, to restore or establish normal function*. Since 2006, Regenerative Medicine has been at the forefront of publishing the very best papers and reviews covering the entire regenerative medicine sector. The journal focusses on the entire spectrum of approaches to regenerative medicine, including small molecule drugs, biologics, biomaterials and tissue engineering, and cell and gene therapies – it’s all about regeneration and not a specific platform technology. The journal’s scope encompasses all aspects of the sector ranging from discovery research, through to clinical development, through to commercialization. Regenerative Medicine uniquely supports this important area of biomedical science and healthcare by providing a peer-reviewed journal totally committed to publishing the very best regenerative medicine research, clinical translation and commercialization. Regenerative Medicine provides a specialist forum to address the important challenges and advances in regenerative medicine, delivering this essential information in concise, clear and attractive article formats – vital to a rapidly growing, multidisciplinary and increasingly time-constrained community. Despite substantial developments in our knowledge and understanding of regeneration, the field is still in its infancy. However, progress is accelerating. The next few decades will see the discovery and development of transformative therapies for patients, and in some cases, even cures. Regenerative Medicine will continue to provide a critical overview of these advances as they progress, undergo clinical trials, and eventually become mainstream medicine.
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