研究摘要:2型糖尿病和慢性肾脏病患者使用非格列酮后的心血管和肾脏疗效--FIDELITY汇总分析。

IF 3.8 3区 医学 Q2 Medicine
Diabetes Therapy Pub Date : 2024-09-01 Epub Date: 2024-07-19 DOI:10.1007/s13300-024-01591-w
Karin Humle, Boris Klanger, Peter Kolkhof, Sylvia E Rosas, Peter Rossing, Eugene Wright, Nichole Jefferson
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引用次数: 0

摘要

2 型糖尿病 (T2D) 和慢性肾脏病 (CKD) 患者面临 CKD 进展和肾衰竭的风险。这是 FIDELITY 汇总分析的摘要,其中的两项临床试验(FIDELIO-DKD 和 FIGARO-DKD)旨在研究非格列酮对 T2D 和 CKD 患者的安全性和有效性。综合分析这两项研究的数据后发现,与服用安慰剂的患者相比,在服用标准护理药物的基础上服用非格列酮者发生心血管事件的风险降低了 14%,发生肾脏事件的风险降低了 23%。服用非格列酮者也更有可能出现高血钾,但这种情况大多是可以控制的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Summary of Research: Cardiovascular and Kidney Outcomes with Finerenone in Patients with Type 2 Diabetes and Chronic Kidney Disease-The FIDELITY Pooled Analysis.

Summary of Research: Cardiovascular and Kidney Outcomes with Finerenone in Patients with Type 2 Diabetes and Chronic Kidney Disease-The FIDELITY Pooled Analysis.

People living with type 2 diabetes (T2D) and chronic kidney disease (CKD) are at risk of CKD progression and kidney failure. This is a summary of the FIDELITY pooled analysis where two clinical trials (FIDELIO-DKD and FIGARO-DKD) were performed to investigate the safety and efficacy of finerenone in people with T2D and CKD. The data from these two studies were combined and analyzed and it was found that those who took finerenone on top of standard-of-care medicine had a 14% reduced risk of having a cardiovascular event and 23% reduced risk of having a kidney event versus those who took placebo. Those who took finerenone were also more likely to have high blood potassium, but this was mostly manageable.A graphical abstract and translations of all content (Chinese, Japanese, German, Spanish, Brazilian-Portuguese, French) are available for this article.

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来源期刊
Diabetes Therapy
Diabetes Therapy Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
6.90
自引率
7.90%
发文量
130
审稿时长
6 weeks
期刊介绍: Diabetes Therapy is an international, peer reviewed, rapid-publication (peer review in 2 weeks, published 3–4 weeks from acceptance) journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of therapeutics and interventions (including devices) across all areas of diabetes. Studies relating to diagnostics and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Diabetes Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research.
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