心脏手术后的急性肾损伤。

IF 2.4 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiorenal Medicine Pub Date : 2024-01-01 Epub Date: 2024-07-18 DOI:10.1159/000540396

Thomas M Beaver, Bhagwan Dass, Ami M Patel, A Ahsan Ejaz

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引用次数: 0

摘要

与心脏手术相关的急性肾损伤（CS-AKI）仍然是一个令人头疼的问题。尽管最初基于实验数据的研究热情高涨，但预防 CS-AKI 的临床试验却令人失望。实验和临床数据的分裂引发了我们对 CS-AKI 以及实验和临床前模型的重新认识。其中的一线希望是各国学会提出的麻醉和围手术期护理标准化。在这篇综述中，我们将讨论主要临床试验的治疗目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Acute Kidney Injury after Cardiac Surgery.

Background: Cardiac surgery-associated acute kidney injury (CS-AKI) remains a vexing issue. Clinical trials for the prevention of CS-AKI have been disappointing despite enormous initial enthusiasm based on experimental data.

Summary: The schism in experimental and clinical data has triggered a relook at our understanding of CS-AKI and the experimental and preclinical models. In this review, we discuss the therapeutic targets of major clinical trials.

Key messages: The silver lining in the midst is the standardization of anesthetic and perioperative care proposed by national societies. Implementation of the KDIGO bundle is a reasonable option to decrease the incidence of CS-AKI despite lack of proven robust benefits.

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来源期刊

Cardiorenal Medicine CARDIAC & CARDIOVASCULAR SYSTEMS-UROLOGY & NEPHROLOGY

CiteScore

5.40

自引率

2.60%

发文量

审稿时长

>12 weeks

期刊介绍： The journal ''Cardiorenal Medicine'' explores the mechanisms by which obesity and other metabolic abnormalities promote the pathogenesis and progression of heart and kidney disease (cardiorenal metabolic syndrome). It provides an interdisciplinary platform for the advancement of research and clinical practice, focussing on translational issues.