可可提取物可诱导白色脂肪细胞棕色化,并改善高脂饮食小鼠的葡萄糖不耐受症。

IF 1.4 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Eito Yonemoto, Risa Ihara, Emi Tanaka, Takakazu Mitani
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引用次数: 0

摘要

可可提取物(CE)具有多种健康益处,如抗肥胖和改善葡萄糖耐受性。然而,其中的机理仍不清楚。脂肪组织包括白色脂肪组织(WAT)和棕色脂肪组织。棕色脂肪组织通过解偶联蛋白 1(UCP1)将脂质代谢为热量,从而减少体内脂肪。白色脂肪细胞转化为棕色样脂肪细胞(米色脂肪细胞)被称为棕色化,它有助于抗肥胖效果和改善葡萄糖耐量。本研究旨在从棕色化的角度评估 CE 对葡萄糖耐量的影响。我们发现,膳食补充 CE 能改善高脂饮食小鼠的葡萄糖耐受性,并能提高腹股沟脂肪细胞中 Ucp1 和棕色化相关基因的表达水平。此外,在小鼠的原发性脂肪细胞中,CE 通过β3-肾上腺素能受体刺激诱导 Ucp1 的表达。这些结果表明,膳食纤维素可通过诱导腹股沟脂肪褐变改善葡萄糖不耐受。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cocoa extract induces browning of white adipocytes and improves glucose intolerance in mice fed a high-fat diet.

Cocoa extract (CE) offers several health benefits, such as antiobesity and improved glucose intolerance. However, the mechanisms remain unclear. Adipose tissue includes white adipose tissue (WAT) and brown adipose tissue. Brown adipose tissue leads to body fat reduction by metabolizing lipids to heat via uncoupling protein 1 (UCP1). The conversion of white adipocytes into brown-like adipocytes (beige adipocytes) is called browning, and it contributes to the anti-obesity effect and improved glucose tolerance. This study aimed to evaluate the effect of CE on glucose tolerance in terms of browning. We found that dietary supplementation with CE improved glucose intolerance in mice fed a high-fat diet, and it increased the expression levels of Ucp1 and browning-associated gene in inguinal WAT. Furthermore, in primary adipocytes of mice, CE induced Ucp1 expression through β3-adrenergic receptor stimulation. These results suggest that dietary CE improves glucose intolerance by inducing browning in WAT.

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来源期刊
Bioscience, Biotechnology, and Biochemistry
Bioscience, Biotechnology, and Biochemistry 生物-生化与分子生物学
CiteScore
3.50
自引率
0.00%
发文量
183
审稿时长
1 months
期刊介绍: Bioscience, Biotechnology, and Biochemistry publishes high-quality papers providing chemical and biological analyses of vital phenomena exhibited by animals, plants, and microorganisms, the chemical structures and functions of their products, and related matters. The Journal plays a major role in communicating to a global audience outstanding basic and applied research in all fields subsumed by the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA).
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