Melika Mirbod, Cyrus Ayubcha, Hyae Won Kim Redden, Eric Teichner, Robert C. Subtirelu, Raj Patel, William Raynor, Thomas Werner, Abass Alavi, Mona-Elisabeth Revheim
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引用次数: 0
摘要
原发性进行性失语(PPA)是一种已知会影响左半球额叶和颞叶区域的疾病。PPA 通常是未来痴呆发展的征兆,特别是额颞叶痴呆(FTD)的语义痴呆(SD)和作为阿尔茨海默病(AD)非典型表现的对数进行性失语(LPA)。本综述旨在阐明 2-脱氧-2-[18F]氟-D-葡萄糖(FDG)-正电子发射断层扫描(PET)在检测和诊断 PPA 中的价值。我们利用 Web of Science、PubMed 和 Google Scholar 对文献进行了全面回顾。三种 PPA 亚型在 FDG-PET 成像中显示出不同的代谢低下区域,SD 位于颞叶前部,LPA 位于左侧颞顶叶交界处,而非流利/语法变异型 PPA(nfvPPA)则位于左侧额叶下回和岛叶。尽管模式不同,但重叠的低代谢区会使鉴别诊断复杂化,尤其是在经常被诊断为注意力缺失症的 SD 患者中。与其他诊断工具相结合可以完善诊断过程,改善患者的预后。未来的研究应侧重于在更大的人群中验证这些发现,并探索早期、准确的 PPA 诊断与更有针对性的治疗干预的治疗意义。
FDG-PET in the diagnosis of primary progressive aphasia: a systematic review
Primary progressive aphasia (PPA) is a disease known to affect the frontal and temporal regions of the left hemisphere. PPA is often an indication of future development of dementia, specifically semantic dementia (SD) for frontotemporal dementia (FTD) and logopenic progressive aphasia (LPA) as an atypical presentation of Alzheimer’s disease (AD). The purpose of this review is to clarify the value of 2-deoxy-2-[18F]fluoro-D-glucose (FDG)-positron emission tomography (PET) in the detection and diagnosis of PPA. A comprehensive review of literature was conducted using Web of Science, PubMed, and Google Scholar. The three PPA subtypes show distinct regions of hypometabolism in FDG-PET imaging with SD in the anterior temporal lobes, LPA in the left temporo-parietal junction, and nonfluent/agrammatic Variant PPA (nfvPPA) in the left inferior frontal gyrus and insula. Despite the distinct patterns, overlapping hypometabolic areas can complicate differential diagnosis, especially in patients with SD who are frequently diagnosed with AD. Integration with other diagnostic tools could refine the diagnostic process and lead to improved patient outcomes. Future research should focus on validating these findings in larger populations and exploring the therapeutic implications of early, accurate PPA diagnosis with more targeted therapeutic interventions.
期刊介绍:
Annals of Nuclear Medicine is an official journal of the Japanese Society of Nuclear Medicine. It develops the appropriate application of radioactive substances and stable nuclides in the field of medicine.
The journal promotes the exchange of ideas and information and research in nuclear medicine and includes the medical application of radionuclides and related subjects. It presents original articles, short communications, reviews and letters to the editor.