聚硅氧烷聚(碳酸酯尿烷脲增强聚硅氧烷(碳酸酯聚氨酯脲)机械性能、润滑性以及血液和生物相容性的策略

IF 4.5 3区 工程技术 Q1 CHEMISTRY, APPLIED
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引用次数: 0

摘要

在与血液接触的材料中加入齐聚物已被证明是一种有效且方便的策略,可最大限度地减少蛋白质吸附和血小板沉积,但往往会损害其机械性能。本文合成并评估了一种含 29.0 mol% 磺基甜菜碱(SB)的硅氧烷聚(碳酸酯聚氨酯脲)(SSiPCUU)。虽然经共聚物改性后,其平衡吸水率提高到 1.20%,明显降低了耐水解降解性和机械性能,但其在湿态下的最大拉伸应力和撕裂强度仍保持所有测试样品中的最高值,这是因为由其产生的脲基形成了分叉氢键,与悬垂 SB 物形成的独特离子簇一起对机械性能做出了重大贡献。由于加入了齐聚物,它表现出极低的摩擦系数,这表明它在潮湿环境中具有极佳的润滑性,无需任何后处理。因此,非特异性蛋白质吸附和血小板粘附都明显降低。此外,它还具有良好的透明度。高润滑性能有利于减少对人体血管的损伤,而良好的透明度则有利于导管中液体流动的可视化。这些结果表明,齐聚物 SSiPCUU 在制备球囊导管、人造血管、支架覆盖物和其他与血液接触的医疗植入物和设备方面具有巨大的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Zwitterionic modification: A strategy to enhance the mechanical properties, lubricity and hemo- and biocompatibility of silicone poly(carbonate urethane urea)

Zwitterionic modification: A strategy to enhance the mechanical properties, lubricity and hemo- and biocompatibility of silicone poly(carbonate urethane urea)

Incorporating zwitterions into the blood-contacting materials has been demon-strated an effective and convenient strategy to minimize protein adsorption and platelet deposition, but is frequently detrimental to the mechanical properties. Herein a feeding 29.0 mol% sulfobetaine (SB) siloxane poly(carbonate urethane urea) (SSiPCUU) was synthesized and evaluated. Although the equilibrium water uptake ratio was increased to 1.20% markedly depressing the hydrolytic degradation resistance and mechanical properties after the zwitterionic modification, its maximum tensile stress and tear strength in the wet state still kept the highest among all the tested samples because the urea groups created therefrom gave rise to the formation of bifurcating hydrogen bonds making a significant contribution to the mechanical properties alongside the unique ion clusters formed from pendant SB species. As a consequence of zwitterionic incorporation, it exhibited an extremely low friction coefficient indicating an excellent lubricity in a wet environment without any post-treatment. Accordingly, both the nonspecific protein adsorption and platelet adhesion were evidently decreased. Moreover, it also depicted a good transparency. The high lubrication performance is desirable for lessening the damage to human blood vessels and a good transparency is favorable to the visualization of the flow of liquid in the catheter. These results illustrated the great potential of the zwitterionic SSiPCUU used in the preparation of balloon catheters, artificial blood vessels, stent coverings and other blood-contacting medical implants and devices.

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来源期刊
Reactive & Functional Polymers
Reactive & Functional Polymers 工程技术-高分子科学
CiteScore
8.90
自引率
5.90%
发文量
259
审稿时长
27 days
期刊介绍: Reactive & Functional Polymers provides a forum to disseminate original ideas, concepts and developments in the science and technology of polymers with functional groups, which impart specific chemical reactivity or physical, chemical, structural, biological, and pharmacological functionality. The scope covers organic polymers, acting for instance as reagents, catalysts, templates, ion-exchangers, selective sorbents, chelating or antimicrobial agents, drug carriers, sensors, membranes, and hydrogels. This also includes reactive cross-linkable prepolymers and high-performance thermosetting polymers, natural or degradable polymers, conducting polymers, and porous polymers. Original research articles must contain thorough molecular and material characterization data on synthesis of the above polymers in combination with their applications. Applications include but are not limited to catalysis, water or effluent treatment, separations and recovery, electronics and information storage, energy conversion, encapsulation, or adhesion.
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