{"title":"MicroRNA 在调节神经退行性疾病相关基因中的作用","authors":"Joao Vitor Carvalho Piasentim, Samya Nogueira Asseiss","doi":"10.15406/ijmboa.2024.07.00174","DOIUrl":null,"url":null,"abstract":"Neurodegenerative diseases pose significant challenges to public health worldwide. MicroRNAs (miRNAs) have emerged as critical regulators of gene expression and are implicated in the pathogenesis of various neurodegenerative disorders. This review comprehensively explores the current understanding of how miRNAs influence gene networks involved in Alzheimer disease, Parkinson disease and amyotrophic lateral sclerosis. We discuss the mechanisms by which miRNAs modulate disease associated genes, their potential as diagnostic biomarkers, and therapeutic targets in neurodegeneration.","PeriodicalId":179796,"journal":{"name":"International Journal of Molecular Biology Open Access","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Role of MicroRNAs in regulating genes related to neurodegenerative diseases\",\"authors\":\"Joao Vitor Carvalho Piasentim, Samya Nogueira Asseiss\",\"doi\":\"10.15406/ijmboa.2024.07.00174\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Neurodegenerative diseases pose significant challenges to public health worldwide. MicroRNAs (miRNAs) have emerged as critical regulators of gene expression and are implicated in the pathogenesis of various neurodegenerative disorders. This review comprehensively explores the current understanding of how miRNAs influence gene networks involved in Alzheimer disease, Parkinson disease and amyotrophic lateral sclerosis. We discuss the mechanisms by which miRNAs modulate disease associated genes, their potential as diagnostic biomarkers, and therapeutic targets in neurodegeneration.\",\"PeriodicalId\":179796,\"journal\":{\"name\":\"International Journal of Molecular Biology Open Access\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Molecular Biology Open Access\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15406/ijmboa.2024.07.00174\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Molecular Biology Open Access","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15406/ijmboa.2024.07.00174","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The Role of MicroRNAs in regulating genes related to neurodegenerative diseases
Neurodegenerative diseases pose significant challenges to public health worldwide. MicroRNAs (miRNAs) have emerged as critical regulators of gene expression and are implicated in the pathogenesis of various neurodegenerative disorders. This review comprehensively explores the current understanding of how miRNAs influence gene networks involved in Alzheimer disease, Parkinson disease and amyotrophic lateral sclerosis. We discuss the mechanisms by which miRNAs modulate disease associated genes, their potential as diagnostic biomarkers, and therapeutic targets in neurodegeneration.
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