Development and Assessment of Helicteres isora Extract Loaded Phospholipid Complex for Anti-Nociceptive Activity

Its primary objective is to assess the efficacy of a phospholipid complex formulation containing an extract of Helicteres isora in reducing inflammation, to determine its progress and evaluation. An Indian Screw Tree, also known as Helicteres isora, is an extremely healing plant. In addition to improving solubility and stability, the phospholipid complex formulation also increases bioavailability and efficacy. This formulation was created by combining Helicteres isora extract with phospholipids using a technique known as phospholipid complexation. Several parameters were evaluated to evaluate the formulation, including particle size, zeta potential, encapsulation efficiency, and drug release profile. Using both in vitro and in vivo models, the anti-inflammatory properties of a phospholipid complex formulation of Helicteres isora were assessed. The experiments were conducted using a rat model of carrageenan-induced paw edema. In this work, phospholipid complex formulations were shown to have improved physicochemical properties, including smaller particle sizes and higher encapsulation rates. According to the results of the in vivo evaluation, phospholipid complex formulations significantly reduced paw edema compared with plain extracts, indicating improved anti-inflammatory activity. The bioavailability, anti-inflammatory activity, and bioavailability of Helicteres isora extract are enhanced by the phospholipid complex formulation.