肿瘤微环境的表观遗传调控：胰腺癌的主导力量

IF 2.8 2区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Pancreatology Pub Date : 2024-09-01 DOI:10.1016/j.pan.2024.07.005

Renzo Vera , María Julia Lamberti , Alina L. Gonzalez , Martín E. Fernandez-Zapico

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引用次数: 0

摘要

肿瘤细胞表观基因组景观的失调与胰腺癌的发病机制有关。然而，这些改变不仅限于肿瘤细胞。肿瘤基质中其他细胞群（如癌症相关成纤维细胞、免疫细胞等）的行为大多受表观遗传途径的调控。在此，我们概述了胰腺癌肿瘤微环境的主要细胞和细胞成分，并讨论了表观遗传机制如何在基质的不同水平上发挥作用，建立差异化的基因表达，从而调控导致胰腺肿瘤发生的不同细胞表型。

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Epigenetic regulation of the tumor microenvironment: A leading force driving pancreatic cancer

Dysregulation of the epigenomic landscape of tumor cells has been implicated in the pathogenesis of pancreatic cancer. However, these alterations are not only restricted to neoplastic cells. The behavior of other cell populations in the tumor stroma such as cancer-associated fibroblasts, immune cells, and others are mostly regulated by epigenetic pathways. Here, we present an overview of the main cellular and acellular components of the pancreatic cancer tumor microenvironment and discuss how the epigenetic mechanisms operate at different levels in the stroma to establish a differential gene expression to regulate distinct cellular phenotypes contributing to pancreatic tumorigenesis.

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来源期刊

Pancreatology 医学-胃肠肝病学

CiteScore

7.20

自引率

5.60%

发文量

194

审稿时长

44 days

期刊介绍： Pancreatology is the official journal of the International Association of Pancreatology (IAP), the European Pancreatic Club (EPC) and several national societies and study groups around the world. Dedicated to the understanding and treatment of exocrine as well as endocrine pancreatic disease, this multidisciplinary periodical publishes original basic, translational and clinical pancreatic research from a range of fields including gastroenterology, oncology, surgery, pharmacology, cellular and molecular biology as well as endocrinology, immunology and epidemiology. Readers can expect to gain new insights into pancreatic physiology and into the pathogenesis, diagnosis, therapeutic approaches and prognosis of pancreatic diseases. The journal features original articles, case reports, consensus guidelines and topical, cutting edge reviews, thus representing a source of valuable, novel information for clinical and basic researchers alike.