Iffatricia Haura Febiriana , Dipo Aldila , Bevina Desjwiandra Handari , Puji Budi Setia Asih , Muhamad Hifzhudin Noor Aziz
{"title":"探索疟疾控制计划中社会意识与蚊帐使用之间的相互作用","authors":"Iffatricia Haura Febiriana , Dipo Aldila , Bevina Desjwiandra Handari , Puji Budi Setia Asih , Muhamad Hifzhudin Noor Aziz","doi":"10.1016/j.jobb.2024.06.005","DOIUrl":null,"url":null,"abstract":"<div><p>This research aims to understand the effect of human awareness and the use of bed nets on malaria control programs. A deterministic host-vector mathematical model was utilized and simplified using the Quasi-Steady State Approximation, assuming the mosquito population is at equilibrium due to its fast, dynamic behavior. The model reveals two equilibrium states: the malaria-free equilibrium and the endemic equilibrium. The malaria-free equilibrium is locally asymptotically stable when the basic reproduction number is less than one and unstable if it is larger than one. Conversely, the malaria-endemic equilibrium is unique and stable if the reproduction number exceeds one and does not exist otherwise. Based on incidence data from Papua, parameter estimation and sensitivity analyses indicate that human awareness and the use of bed nets significantly reduce the reproduction number. To address budget constraints for interventions, the model was reformulated as an optimal control problem, characterized using the Pontryagin Maximum Principle, and solved with the forward–backward sweep method. Numerical experiments were conducted to assess the impact of various scenarios on the malaria control program. Cost-effectiveness analyses employing ACER, ICER, and IAR metrics suggest that while the combined implementation of awareness campaigns and bed nets effectively reduces infections, it incurs high costs. In contrast, implementing human awareness campaigns alone emerges as the best strategy based on ACER, ICER, and IAR standards. This study demonstrates that enhancing human awareness and promoting the use of bed nets are effective strategies for controlling malaria. However, due to budget constraints, focusing solely on awareness campaigns proves to be the most cost-effective intervention. This approach not only reduces malaria transmission but also optimizes resource allocation, highlighting the importance of targeted educational programs in public health initiatives for malaria control.</p></div>","PeriodicalId":52875,"journal":{"name":"Journal of Biosafety and Biosecurity","volume":"6 3","pages":"Pages 196-210"},"PeriodicalIF":0.0000,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2588933824000359/pdfft?md5=286803da5b7a0c85dfa5ff19326db67a&pid=1-s2.0-S2588933824000359-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Exploring the Interplay Between Social Awareness and the Use of Bed Nets in a Malaria Control Program\",\"authors\":\"Iffatricia Haura Febiriana , Dipo Aldila , Bevina Desjwiandra Handari , Puji Budi Setia Asih , Muhamad Hifzhudin Noor Aziz\",\"doi\":\"10.1016/j.jobb.2024.06.005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>This research aims to understand the effect of human awareness and the use of bed nets on malaria control programs. A deterministic host-vector mathematical model was utilized and simplified using the Quasi-Steady State Approximation, assuming the mosquito population is at equilibrium due to its fast, dynamic behavior. The model reveals two equilibrium states: the malaria-free equilibrium and the endemic equilibrium. The malaria-free equilibrium is locally asymptotically stable when the basic reproduction number is less than one and unstable if it is larger than one. Conversely, the malaria-endemic equilibrium is unique and stable if the reproduction number exceeds one and does not exist otherwise. Based on incidence data from Papua, parameter estimation and sensitivity analyses indicate that human awareness and the use of bed nets significantly reduce the reproduction number. To address budget constraints for interventions, the model was reformulated as an optimal control problem, characterized using the Pontryagin Maximum Principle, and solved with the forward–backward sweep method. Numerical experiments were conducted to assess the impact of various scenarios on the malaria control program. Cost-effectiveness analyses employing ACER, ICER, and IAR metrics suggest that while the combined implementation of awareness campaigns and bed nets effectively reduces infections, it incurs high costs. In contrast, implementing human awareness campaigns alone emerges as the best strategy based on ACER, ICER, and IAR standards. This study demonstrates that enhancing human awareness and promoting the use of bed nets are effective strategies for controlling malaria. However, due to budget constraints, focusing solely on awareness campaigns proves to be the most cost-effective intervention. This approach not only reduces malaria transmission but also optimizes resource allocation, highlighting the importance of targeted educational programs in public health initiatives for malaria control.</p></div>\",\"PeriodicalId\":52875,\"journal\":{\"name\":\"Journal of Biosafety and Biosecurity\",\"volume\":\"6 3\",\"pages\":\"Pages 196-210\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-07-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2588933824000359/pdfft?md5=286803da5b7a0c85dfa5ff19326db67a&pid=1-s2.0-S2588933824000359-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Biosafety and Biosecurity\",\"FirstCategoryId\":\"1093\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2588933824000359\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Social Sciences\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biosafety and Biosecurity","FirstCategoryId":"1093","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2588933824000359","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Social Sciences","Score":null,"Total":0}
引用次数: 0
摘要
这项研究旨在了解人类意识和蚊帐的使用对疟疾控制计划的影响。研究利用了一个确定性宿主-媒介数学模型,并使用准稳态近似法进行了简化,假设蚊子种群因其快速、动态的行为而处于平衡状态。该模型揭示了两种平衡状态:无疟疾平衡和地方病平衡。当基本繁殖数小于 1 时,无疟疾平衡是局部渐近稳定的;当基本繁殖数大于 1 时,无疟疾平衡是不稳定的。相反,如果繁殖数大于 1,疟疾流行均衡是唯一且稳定的,否则不存在。根据巴布亚的发病率数据,参数估计和敏感性分析表明,人的意识和蚊帐的使用能显著降低繁殖数。为解决干预措施的预算限制问题,该模型被重新表述为一个最优控制问题,利用庞特里亚金最大原则对其进行表征,并采用前向-后向扫频方法进行求解。通过数值实验评估了各种方案对疟疾控制计划的影响。采用 ACER、ICER 和 IAR 指标进行的成本效益分析表明,虽然联合实施宣传活动和蚊帐能有效降低感染率,但成本较高。相比之下,根据 ACER、ICER 和 IAR 标准,单独开展提高人类意识的活动是最佳策略。这项研究表明,提高人们的意识和推广使用蚊帐是控制疟疾的有效策略。然而,由于预算限制,仅专注于宣传活动被证明是最具成本效益的干预措施。这种方法不仅能减少疟疾传播,还能优化资源分配,突出了有针对性的教育计划在疟疾控制公共卫生行动中的重要性。
Exploring the Interplay Between Social Awareness and the Use of Bed Nets in a Malaria Control Program
This research aims to understand the effect of human awareness and the use of bed nets on malaria control programs. A deterministic host-vector mathematical model was utilized and simplified using the Quasi-Steady State Approximation, assuming the mosquito population is at equilibrium due to its fast, dynamic behavior. The model reveals two equilibrium states: the malaria-free equilibrium and the endemic equilibrium. The malaria-free equilibrium is locally asymptotically stable when the basic reproduction number is less than one and unstable if it is larger than one. Conversely, the malaria-endemic equilibrium is unique and stable if the reproduction number exceeds one and does not exist otherwise. Based on incidence data from Papua, parameter estimation and sensitivity analyses indicate that human awareness and the use of bed nets significantly reduce the reproduction number. To address budget constraints for interventions, the model was reformulated as an optimal control problem, characterized using the Pontryagin Maximum Principle, and solved with the forward–backward sweep method. Numerical experiments were conducted to assess the impact of various scenarios on the malaria control program. Cost-effectiveness analyses employing ACER, ICER, and IAR metrics suggest that while the combined implementation of awareness campaigns and bed nets effectively reduces infections, it incurs high costs. In contrast, implementing human awareness campaigns alone emerges as the best strategy based on ACER, ICER, and IAR standards. This study demonstrates that enhancing human awareness and promoting the use of bed nets are effective strategies for controlling malaria. However, due to budget constraints, focusing solely on awareness campaigns proves to be the most cost-effective intervention. This approach not only reduces malaria transmission but also optimizes resource allocation, highlighting the importance of targeted educational programs in public health initiatives for malaria control.