大鼠后肢缺血模型中腓肠肌的病理变化

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-02 DOI:10.47056/0365-9615-2024-177-1-31-35

V. M. Pavlov, A. Y. Fedotova, M. V. Shinelev, V. Palikov, A. V. Zamyatina, N. A. Borozdina, D. Atyakshin, O. I. Patsap, M. A. Ignatyuk, S. Semushina, D. A. Bondarenko, I. A. Dyachenko

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引用次数: 0

摘要

我们介绍了一种用于研究大鼠慢性后肢缺血的两阶段模型。缺血区出现了横纹肌细胞萎缩和血管减少的硬化变化。内皮中 CD31 的表达与缺血区的血管数量成比例增加，同时在新形成的神经纤维中检测到βⅢ-tubulin 的灶性表达。这些组织学特征相当于人类外周动脉疾病的发展过程，因此可以利用我们的模型寻找新的治疗策略。

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Pathological Changes in the Gastrocnemius Muscle throughout Hind Limb Ischemia Modeling in Rats.

We present a two-stage model for the study of chronic hind limb ischemia in rats. In the area of ischemia, sclerotic changes with atrophic rhabdomyocytes and reduced vascularization were revealed. CD31 expression in the endothelium increased proportionally to the number of vessels in the ischemic zone, and at the same time, focal expression of βIII-tubulin was detected in the newly formed nerve fibers. These histological features are equivalent to the development of peripheral arterial disease in humans, which allows using our model in the search for new therapeutic strategies.

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.