通过虚拟组织学-血管内超声阐明药物洗脱支架再狭窄患者的中性粒细胞-淋巴细胞比率与斑块构成之间的关系

Ming Yu, Yuxing Wang, Song Yang, Jiajie Mei, Zhenzhu Liu, Lijiao Zhang, Wenli Xie, Zhaohong Geng, Baole Liu, Hongyan Wang, Peng Qu, N. Niu
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引用次数: 0

摘要

(1) 背景:支架内再狭窄(ISR)是影响预后和靶病变血管再通的主要因素。斑块的组成尚不清楚,因此,研究 ISR 的组成以确定临床干预标记物至关重要。(2)方法:本研究对 36 例药物洗脱支架再狭窄患者进行了研究。根据 36 例患者的中位 NLR 水平,将患者分为低中性粒细胞-淋巴细胞比值(L-NLR)和高中性粒细胞-淋巴细胞比值(H-NLR)。对基线数据、生化检查、心脏超声数据等现有信息中的不一致之处进行了研究,以确定潜在的危险因素,并对斑块特性进行了多因素线性回归分析。(3)结果:根据 NLR = 2.64 将 18 名患者分为 L-NLR 组,18 名患者分为 H-NLR 组。在年龄、经皮冠状动脉介入治疗(PCI)前 SYNTAX II 评分、C 反应蛋白(CRP)、白细胞介素(IL)-6、斑块负荷、纤维脂质组织面积、钙化瘤和虚拟组织学-薄纤维帽动脉粥样硬化(VH-TCFA)方面,差异有统计学意义。通过多因素线性回归,确定了年龄、中性粒细胞-淋巴细胞比值(NLR)水平和 IL-6 水平的变化对斑块应力和虚拟组织学血管内超声(VH-IVUS)中纤维脂质组织百分比的重要影响。(4)结论:高 NLR 组心肌损伤严重程度增加,与较高的 SYNTAX II 评分、较高的斑块负荷和较高的易损成分比例一致。事实证明,NLR既是斑块负荷的危险因素,也是ISR中纤维脂肪组织比例的危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Elucidating the Relationship between Neutrophil–Lymphocyte Ratio and Plaque Composition in Patients with Drug-Eluting Stent Restenosis by Virtual Histology-Intravascular Ultrasound
(1) Background: In-stent Restenosis (ISR) is a major factor influencing the prognosis and revascularization of target lesions. The plaque composition is unclear; therefore, it is critical to investigate ISR composition to identify clinical intervention markers. (2) Methods: This study was conducted on 36 patients with drug-eluting stent restenosis. The patients were classified into a Low Neutrophil–Lymphocyte Ratio (L-NLR) and High Neutrophil–Lymphocyte Ratio (H-NLR) according to the median NLR level of 36 patients. Discrepancies in the current information such as baseline data, biochemical examination, cardiac ultrasound data, etc., were examined to identify the underlying risk factors, and a multifactorial linear regression analysis of plaque properties was conducted. (3) Results: NLR = 2.64 was utilized to classify 18 patients into the L-NLR group and 18 patients into the H-NLR group. There were statistically significant differences in age, a pre-percutaneous coronary intervention (PCI) SYNTAX II score, a C-reactive protein (CRP), interleukin (IL)-6, plaque loading, a fibro-lipid tissue area, calcified nubs, and virtual histology-thin fibrous cap atherosclerotic (VH-TCFA). The significant impacts of variations in age, neutrophil–lymphocyte ratio (NLR) levels, and IL-6 levels on the plaque stress and percentage of the fibro-lipid tissue in virtual histology-intravascular ultrasound (VH-IVUS) were identified through multifactorial linear regression. (4) Conclusions: The high NLR group demonstrated increased myocardial injury severity, consistent with higher SYNTAX II scores, a higher plaque burden, and higher proportions of vulnerable components. NLR proved to be a risk factor for both the plaque load and the proportion of the fibro-lipid tissue in ISR.
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