Clinical Evaluation of Use Decellularized Cartilage as a Bio Scaffold for the Repair of Articular Cartilage in Dogs with Osteoarthritis

Articular cartilage lacks the ability to repair itself because it is devoid of blood vessels, nerves, and lymph, and there is no effective treatment that contributes to the cartilage repair process. Osteoarthritis (OA) represents a difficult challenge and an increasing health care burden  worldwide. Nowadays, the generation of scaffolds has received great and increasing attention in order to preserve the biophysical environment and bioactive factors. In addition, improved decellularization technology has contributed to providing new promising solutions in the treatment of OA. Osteoarthritis (OA): Osteoarthritis (OA)is a common and debilitating joint disease that effects of dogs worldwide. Treating cartilage abnormalities is challenging due to the restricted regenerative capacity of cartilage and the constraints of existing therapies. Therefore, there is a need for novel and innovative therapies that can target the underlying causes of osteoarthritis and promote cartilage regeneration. This study was conducted to evaluate the efficacy of decellularized cartilage for treating full-thickness defects of articular cartilage in dogs. Methodology: Methodology ten dogs, healthy adult cross-breed, they were divided  into two equal groups, Group I (the control group) was left without treatment. While group II (the DC group) was treated by the application of decellularized cartilage, in this research, we investigated the utilization of decellularized xenograft articular cartilage is treatment can, the dogs were euthanized on day 56 after surgery. Clinical, macroscopic evaluations were  performed. Results: Results statically analysis of pain, lameness at walking and trot showed effectively reduce pain and improve functionality in severe stifle osteoarthritis. Macroscopically, the fibrous tissue appeared to fill the gap with the complete absence of the bone marrow of the decellularized cartilage group compare with control group. Conclusion: Conclusion decellularized cartilage used as a treatment can effectively reduce pain, enhance movement and accelerate cartilage regeneration.