Antibiotic resistance as a medical problem

The growth and spread of antimicrobial resistance (AMR) is one of the main threats to the healthcare system. Currently, along with the development of new antimicrobial drugs (AMPs) the basic approach to countering the spread of AMR is the rational use of existing medicines. Selection of the optimal drug taking into account its activity, doses, frequency and route of administration are the basis of rational antimicrobial therapy. However, due to widespread availability of AMR, availability of up-to-date information on activity of AMP is extremely important. Therefore, monitoring of antibiotic resistance is a key activity to ensure providing the evidence base on which antimicrobial formularies should be drawn up drugs and treatment protocols. In the solution of these problems in the Russian Federation active role plaies the Methodological Verification Center on Antimicrobial Resistance – Reference center for clinical pharmacology, created on the basis of the Research Institute of Antimicrobial Chemotherapy of the Smolensk State Medical University of the Ministry of Health of Russian Federation.