6至12岁儿童的脂肪率、血清维生素D和膳食质量与心脏代谢风险的关系：马来西亚 SEANUTS II 研究结果

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-07-04 DOI:10.1139/apnm-2023-0621

Kai Sze Chan, Farah Nor MF, Giin Shang Yeo, Kuan Chiet Teh, Shoo Thien Lee, Ika Aida Aprilini Makbul, Nor Aini Jamil, R. Sharif, J. Wong, I. Khouw, B. Poh, S. ‎

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引用次数: 0

摘要

有证据表明，肥胖、饮食和血清 25- 羟基维生素 D（25(OH)D）与心脏代谢风险有关，儿童心脏代谢风险的增加正日益成为人们关注的问题。然而，针对马来西亚儿童的此类研究却很少。因此，本研究探讨了马来西亚 4-12 岁儿童的脂肪含量、饮食质量和 25（OH）D 与心脏代谢风险因素之间的关系。研究分析了马来西亚东南亚营养调查（SEANUTS II）中 4879 名儿童（平均年龄：8.2±2.3 岁，53% 为女性）的数据。采用生物电阻抗技术评估肥胖程度（体脂百分比）。膳食质量通过 24 小时膳食回忆进行评估，并计算出平均充足率 (MAR)。维生素 D 根据血清 25- 羟维生素 D（25(OH)D）进行评估。心脏代谢风险因素的测量包括腰围、平均动脉压、空腹血糖、高密度脂蛋白（HDL）、甘油三酯和高敏C反应蛋白，并计算心脏代谢风险群组得分（siMS）。总体而言，较高的脂肪含量与所有心脏代谢风险因素均呈正相关（WC, ß=0.907; 95%CI=0.865,0.948; MAP, ß=0.225; 95%CI=0.158, 0.292；HDL，ß=-0.011；95%CI=-0.014，-0.009；甘油三酯，ß=0.012；95%CI=0.009，0.016；FBG，ß=0.006；95%CI=0.002，0.011）和 siMS 评分（ß=0.033；95%CI=0.029，0.037）。血清 25（OH）D 与 siMS 评分成反比（ß= -0.002；95%CI= -0.004，-0.000008），与 HDL 成正比（ß=0.002；95%CI=0.0001，0.003）。我们的研究结果表明，肥胖是儿童不良心脏代谢风险因素的关键决定因素，而血清 25（OH）D 可能与整体心脏代谢健康有关。需要采取干预措施减少肥胖，以减轻儿童心脏代谢失调的有害后果。

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Association of Adiposity, Serum Vitamin D and Dietary Quality with Cardiometabolic Risk in Children aged 6 to 12 years: Findings from SEANUTS II Malaysia

Increased cardiometabolic risk among children is increasingly becoming a concern, with evidence indicating that obesity, diet, and serum 25-hydroxyvitamin D (25(OH)D) are associated with cardiometabolic risk. However, such studies among Malaysian children are scarce. Thus, this study explores the associations between adiposity, dietary quality, and 25(OH)D, with cardiometabolic risk factors among Malaysian children aged 4-12 years. Data of 4879 children (mean age: 8.2±2.3 years old, 53% females) from the South East Asian Nutrition Surveys (SEANUTS II) Malaysia, were analysed. Adiposity (percentage of body fat) was assessed with bioelectrical impedance technique. Dietary quality was assessed using 24-hour dietary recall and calculated as mean adequacy ratio (MAR). Vitamin D was assessed based on serum 25-hydroxyvitamin D (25(OH)D). Measurements of cardiometabolic risk factors included waist circumference, mean arterial pressure, fasting blood glucose, high-density lipoprotein (HDL), triglyceride, and high-sensitivity C-reactive protein, and cardiometabolic risk cluster score (siMS) was calculated. Overall, higher adiposity was positively associated with all cardiometabolic risk factors (WC, ß=0.907; 95%CI=0.865,0.948; MAP, ß=0.225; 95%CI=0.158, 0.292; HDL, ß =-0.011; 95%CI=-0.014, -0.009; Triglyceride, ß=0.012; 95%CI=0.009, 0.016; FBG, ß=0.006; 95%CI=0.002, 0.011) and siMS scores (ß=0.033; 95%CI=0.029, 0.037). Serum 25(OH)D was inversely associated with siMS scores (ß= -0.002; 95%CI= -0.004, -0.000008) and positively associated with HDL (ß=0.002; 95%CI=0.0001, 0.003). Our findings suggest that adiposity is a key determinant of adverse cardiometabolic risk factors in children, while serum 25(OH)D may be associated with overall cardiometabolic health. Interventions to reduce obesity are needed to mitigate the deleterious consequences of cardiometabolic dysregulation in children.

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.