用于靶向细胞粘附和增殖的胶原蛋白-磁性微粒复合微珠的制作与表征

Macromol Pub Date : 2024-07-04 DOI:10.3390/macromol4030027
Daichi Tanoshiri, Sakura Inoue, Shigehisa Aoki, Akira Kimoto, Y. Oishi, Takayuki Narita
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引用次数: 0

摘要

胶原蛋白的生物相容性与磁性元件的遥控能力相结合,既可作为细胞支架,也可作为致动器。我们研究了胶原蛋白-磁性颗粒复合微珠(CMPMBs)的制备、表征和潜在应用。研究发现,胶原蛋白浓度、颗粒大小和表面粗糙度之间的相互作用会影响细胞的粘附和增殖。吸附和解吸测试表明,颗粒可逆地附着在磁片上,从而实现了精确的空间控制和定向细胞输送。这些颗粒证明了其作为细胞载体的效用,支持细胞迁移和增殖。这些研究结果展示了 CMPMB 作为先进细胞递送和组织再生应用平台的潜力。微调颗粒特性并利用磁场操纵它们的能力为创建复杂的组织结构和控制细胞行为提供了新的可能性,有助于开发更有效的再生疗法和组织工程方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fabrication and Characterization of Collagen–Magnetic Particle Composite Microbeads for Targeted Cell Adhesion and Proliferation
The integration of the biocompatibility of collagen and the remote-control ability of magnetic elements serves as both a cell scaffold and an actuator. We studied the preparation, characterization, and potential applications of collagen–magnetic particle composite microbeads (CMPMBs). The interplay among collagen concentration, particle size, and surface roughness was found to influence cell adhesion and proliferation. Adsorption and desorption tests showed the reversible attachment of the particles to magnetic sheets, enabling precise spatial control and targeted cell delivery. The particles demonstrated their utility as cell carriers, supporting cell migration and proliferation. These findings showcase the potential of CMPMBs as a promising platform for advanced cell delivery and tissue regeneration applications. The ability to fine-tune particle properties and manipulate them using magnetic fields offers new possibilities for creating complex tissue constructs and controlling cellular behavior, which could contribute to the development of more effective regenerative therapies and tissue engineering approaches.
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