一家三甲医院的艾滋病毒阳性和阴性人群中 1 型和 2 型单纯疱疹病毒感染的血清流行率

Asian Journal of Pharmaceutical and Clinical Research Pub Date : 2024-07-07 DOI:10.22159/ajpcr.2024v17i7.50998

Meghna Sharma, Sapna Soneja, L. Oberoi, Anuradha Malhotra

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引用次数: 0

摘要

研究目的本研究旨在确定人类免疫缺陷病毒（HIV）阳性和非 HIV 患者中单纯疱疹病毒（HSV）的血清流行率及其与 CD-4 细胞计数的关系。方法：本研究从阿姆利则政府医学院临床科室招募了 200 名接受抗逆转录病毒治疗的 HIV 阳性患者和 100 名 HIV 阴性患者。按照制造商的说明，使用抗 HSV-1 免疫球蛋白 G (IgG) 酶联免疫吸附试验 (ELISA)（calbiotech）、抗 HSV-2 免疫球蛋白 G (IgG)（calbiotech）和 HSV-1/2 池 IgM 酶联免疫吸附试验（calbiotech）对血清进行平行检测。Sysmex partec CyFlow counter IVD 流式细胞仪。CD4+ 试剂用于测量 CD4+ T 淋巴细胞的绝对计数：抗 HSV-2 IgG 血清阳性率与 HIV 阳性状态呈正相关。HIV 阳性组（n=163）抗 HSV-2 IgG 患者的平均 CD4+ T 淋巴细胞计数为 400.45±122.92 cells/μL。HSV-2 IgG 阴性病例的平均 CD4+ 细胞数为 350.05±160.46 cells/μL。这一关联具有统计学意义：结论：HSV-1 和 HSV-2 是常见的终身感染疾病，通常没有症状。非洲的研究强调了 HSV 与 HIV 感染的协同作用。关于这种常见感染的血清流行率以及印度北部地区的研究却很少。我们的研究证实了这种合并感染的协同作用。提高对 HSV 与 HIV 协同作用的认识有助于在安全性行为方面做出更明智的决定。

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SEROPREVALENCE OF HERPES SIMPLEX VIRUS INFECTION TYPE 1 AND 2 IN A POPULATION OF HIV-POSITIVE AND HIV-NEGATIVE INDIVIDUALS IN A TERTIARY CARE HOSPITAL

Objectives: The aim of this study is to determine the seroprevalence of herpes simplex virus (HSV) in a population of human immunodeficiency virus (HIV) positive and non-HIV patients and its association with CD-4 count. Methods: 200 HIV-positive individuals attending antiretroviral treatment clinic and 100 HIV-negative individuals from the clinical departments of Government Medical College, Amritsar, were enrolled in the study. The sera were tested in parallel using anti-HSV-1 immunoglobulin G (IgG) enzyme-linked immunosorbent assay (ELISA) (calbiotech), anti-HSV-2-IgG (calbiotech), and HSV-1/2 pool IgM ELISA (calbiotech) assays as per the manufacturer’s instructions. Sysmex partec CyFlow counter IVD flow cytometer. CD4+ reagents are used for measuring absolute counts of CD4+ T lymphocytes. Results: For anti-HSV-2 IgG, seroprevalence was positively associated with HIV-positive status. The mean CD4+ T lymphocyte counts for anti- HSV-2 IgG patients were 400.45±122.92 cells/μL in the HIV-positive group (n=163). Mean CD4+ counts in HSV-2 IgG-negative cases were 350.05±160.46 cells/μL. This association was statistically significant. Conclusion: HSV-1 and 2 are common lifelong infections that often are asymptomatic. African studies have highlighted HSV synergism with HIV infection. Seroprevalence of this common infection and the studies covering the Northern India region are scarce. Our study has confirmed this coinfection synergism. Increasing awareness of HSV-HIV synergy can contribute to better informed decisions regarding safe sex practices.

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Asian Journal of Pharmaceutical and Clinical Research

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