食用芥子油与哈里斯血小板综合征:揭示印度次大陆血小板减少症与饮食的联系

Wasim Ul Haque
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摘要

背景和目的:无症状血小板减少症的特点是血小板计数减少而无出血症状,在印度和孟加拉国的某些地区非常普遍,给诊断带来了挑战。来自孟加拉国和印度各地(尤其是西孟加拉邦)的相当一部分健康献血者表现出这种情况,被称为哈里斯血小板综合征(HPS)。本综述探讨了这些地区常见的主食芥末油消费与 HPS 发病率之间的潜在相关性:方法:采用系统检索策略,在谷歌学术、MEDLINE、PubMed 和 Scopus 等数据库中进行了全面的叙述性综述。关键词包括 "哈里斯血小板综合征"、"食用芥子油"、"血小板减少 "和 "芥酸"。根据相关性和质量选择研究,重点关注 HPS 的流行病学、饮食习惯以及芥酸对血小板减少的影响:结果:HPS 在印度次大陆,尤其是西孟加拉邦、克什米尔和阿萨姆邦等地区的发病率很高。综述发现,在主要使用芥末油的地区,血小板减少症的发病率较高。研究强调了膳食中芥子油中的芥酸与血小板减少之间的关系,在使用含有芥酸的洛伦佐油治疗的患者中观察到了显著的影响:本综述强调了印度次大陆芥子油消费与无症状血小板减少之间的重要关联。HPS 和芥酸诱导的血小板减少症在血液学特征上的相似性强调了进一步研究的必要性。这包括测量患者体内的芥酸水平、进行受控饮食干预和遗传分析以区分遗传和环境因素。DOI:https://doi.org/10.55010/imcjms.18.021*通讯:Wasim Md MohosinUl Haque,孟加拉国糖尿病、内分泌和代谢紊乱研究与康复研究所(BIRDEM)肾脏病学系,孟加拉国达卡-1000,卡齐-纳兹鲁尔-伊斯兰大道 122 号。电子邮件:wmmhaque@live.com
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mustard oil consumption and Harris platelet syndrome: unveiling a dietary link to thrombocytopenia in the Indian subcontinent
Background and objectives: Asymptomatic thrombocytopenia, characterized by a reduced platelet count without bleeding symptoms, is notably prevalent in certain regions of India and Bangladesh, presenting a diagnostic challenge. A significant portion of healthy blood donors from Bangladesh and various parts of India, particularly West Bengal, exhibit this condition, termed Harris platelet syndrome (HPS). This review explores the potential correlation between mustard oil consumption, a common dietary staple in these regions, and the incidence of HPS. Methods: A comprehensive narrative review was conducted using systematic search strategies across databases such as Google Scholar, MEDLINE, PubMed, and Scopus. Keywords included "Harris platelet syndrome," "mustard oil consumption," "thrombocytopenia," and "erucic acid." Studies were selected based on relevance and quality, focusing on the epidemiology of HPS, dietary habits, and the thrombocytopenic effects of erucic acid. Results: HPS shows a significant geographical prevalence in the Indian subcontinent, notably in regions like West Bengal, Kashmir, and Assam. The review identifies a higher prevalence of thrombocytopenia in areas with predominant mustard oil usage. Studies highlight the association between dietary erucic acid from mustard oil and thrombocytopenia, with notable effects observed in patients treated with Lorenzo’s Oil, which contains erucic acid. Conclusions: The review highlights a significant association between mustard oil consumption and asymptomatic thrombocytopenia in the Indian subcontinent. The similarity in hematological profiles between HPS and erucic acid-induced thrombocytopenia underscores the need for further research. This includes measuring erucic acid levels in patients, conducting controlled dietary interventions, and genetic analyses to differentiate between genetic and environmental factors. July 2024; Vol. 18(2):009. DOI:https://doi.org/10.55010/imcjms.18.021 *Correspondence: Wasim Md MohosinUl Haque, Department of Nephrology, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), 122 Kazi Nazrul Islam Avenue, Dhaka-1000, Bangladesh. Email: wmmhaque@live.com
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