通过酒精脱氢与色满-4-酮氨基配体微波辅助合成吡咯、吡啶、色满、香豆素和贝蒂碱

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Danish Khan, Beauty kumari, Abdullah Yahya Abdullah Alzahrani, Neha Dua, Shaily, Nirma Maurya
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引用次数: 0

摘要

本研究概述了一种利用微波辅助进行醇脱氢反应的新方法的开发过程。该过程由锰(II)和钴(II)与色曼-4-酮氨基配体共同催化。这项研究介绍了一种独特的催化系统,该系统能够通过醇脱氢合成各种杂环化合物,包括吡咯、吡啶、贝蒂碱、色原酮和香豆素。合成过程包括使用标准分析技术制备和鉴定一系列铬-4-酮氨基配体(C1-C6)。这些配体与 MnCl2‧4H2O 和 CoCl2 结合使用,显示出显著的催化活性,有效地推动了醇脱氢反应。在反应过程中,金属与配体原位形成络合物,从而启动了催化循环。利用 ESI-MS 进行的表征证实,在整个催化循环过程中存在金属配合物(Int-1)和其他中间产物(Int-II 和 Int-III)。此外,对照实验证实了催化系统的功效,H2 气体的进化证明了这一点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Microwave-assisted Synthesis of Pyrroles, Pyridines, Chromenes, Coumarins, and Betti Bases via Alcohol Dehydrogenation with Chroman-4-one Amino Ligands
This study outlines the development of a novel approach utilizing microwave assistance for the alcohol dehydrogenative reaction. The process is catalyzed by manganese (II) and cobalt (II) in conjunction with chroman-4-one amino ligands. This research introduces a unique catalytic system capable of synthesizing various heterocyclic compounds, including pyrroles, pyridines, Betti bases, chromenes, and coumarins via alcohol dehydrogenation. The synthesis involved the preparation and characterization of a series of chroman-4-one amino ligands (C1-C6) using standard analytical techniques. These ligands, in combination with MnCl2‧4H2O and CoCl2, demonstrated remarkable catalytic activity, effectively driving alcohol dehydrogenation. The catalytic cycle was initiated by the in-situ formation of metal complexes with the ligands during the reaction. Characterization using ESI-MS confirmed the presence of metal complexes (Int-1) and other intermediates (Int-II and Int-III) throughout the catalytic cycle. Additionally, the controlled experiment corroborated the efficacy of the catalytic system, evidenced by the evolution of H2 gas.
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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