Danish Khan, Beauty kumari, Abdullah Yahya Abdullah Alzahrani, Neha Dua, Shaily, Nirma Maurya
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Microwave-assisted Synthesis of Pyrroles, Pyridines, Chromenes, Coumarins, and
Betti Bases via Alcohol Dehydrogenation with Chroman-4-one Amino Ligands
This study outlines the development of a novel approach utilizing microwave assistance for the alcohol dehydrogenative reaction. The process is catalyzed by manganese (II) and cobalt (II) in conjunction with
chroman-4-one amino ligands. This research introduces a unique catalytic system capable of synthesizing various heterocyclic compounds, including pyrroles, pyridines, Betti bases, chromenes, and coumarins via alcohol
dehydrogenation. The synthesis involved the preparation and characterization of a series of chroman-4-one
amino ligands (C1-C6) using standard analytical techniques. These ligands, in combination with MnCl2‧4H2O
and CoCl2, demonstrated remarkable catalytic activity, effectively driving alcohol dehydrogenation. The catalytic cycle was initiated by the in-situ formation of metal complexes with the ligands during the reaction. Characterization using ESI-MS confirmed the presence of metal complexes (Int-1) and other intermediates (Int-II
and Int-III) throughout the catalytic cycle. Additionally, the controlled experiment corroborated the efficacy of
the catalytic system, evidenced by the evolution of H2 gas.
期刊介绍:
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.