治疗肝细胞癌的肿瘤溶解病毒疗法：一种有效的免疫治疗方法

IF 2.5 4区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

World Journal of Gastrointestinal Oncology Pub Date : 2024-07-15 DOI:10.4251/wjgo.v16.i7.2867

Rong Xiao, Hao Jin, Fang Huang, Biao Huang, Hui Wang, Yi-Gang Wang

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引用次数: 0

摘要

肝细胞癌（HCC）是一种恶性程度增高、死亡率高、预后差的全身性疾病。自从肿瘤治疗的免疫机制建立以来，人们已经意识到免疫治疗是改善 HCC 患者预后的有效手段。肿瘤溶解病毒是一种新型的免疫治疗药物，它通过直接裂解肿瘤和诱导抗肿瘤免疫反应来杀死肿瘤细胞，并使正常细胞免于感染，作为一种HCC疗法已被广泛研究。这篇社论讨论了溶瘤病毒治疗 HCC，强调了与 HCC 相关的病毒免疫疗法策略和临床应用。

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Oncolytic virotherapy for hepatocellular carcinoma: A potent immunotherapeutic landscape

Hepatocellular carcinoma (HCC) is a systemic disease with augmented malignant degree, high mortality and poor prognosis. Since the establishment of the immune mechanism of tumor therapy, people have realized that immunotherapy is an effective means for improvement of HCC patient prognosis. Oncolytic virus is a novel immunotherapy drug, which kills tumor cells and exempts normal cells by directly lysing tumor and inducing anti-tumor immune response, and it has been extensively examined as an HCC therapy. This editorial discusses oncolytic viruses for the treatment of HCC, emphasizing viral immunotherapy strategies and clinical applications related to HCC.

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来源期刊

World Journal of Gastrointestinal Oncology Medicine-Gastroenterology

CiteScore

4.20

自引率

3.30%

发文量

1082

期刊介绍： The World Journal of Gastrointestinal Oncology (WJGO) is a leading academic journal devoted to reporting the latest, cutting-edge research progress and findings of basic research and clinical practice in the field of gastrointestinal oncology.