探索 5-磺基水杨酸二水合物作为 3-吡咯啉-2-酮合成催化剂的多功能性

IF 2.8 3区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
Dhananjay D. Gadge, Pramod S. Kulkarni
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引用次数: 0

摘要

我们利用 5-磺基水杨酸二水合物(5-SSA.2H2O)作为有机催化剂,开发了一种单锅四组分合成方法,通过使用二烷基乙酰二甲酸酯、胺和甲醛或芳香醛,在室温下合成多官能团 3-吡咯啉-2-酮分子。这种方法有许多显著的优点,如反应时间短、过程简单且环保、产率高、广泛适用于各种底物,以及使用了一种成本效益高、易于获得且可生物降解的催化剂。利用傅立叶变换红外光谱、1HNMR、13CNMR 和 HRMS 等技术确认了 3-吡咯啉-2-酮分子的结构。总之,这项研究展示了一种在常温下高效、平稳地生产环境友好型多官能团 3-吡咯啉-2-酮的可行方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Exploring the versatility of 5-sulfosalicylic acid dihydrate as catalyst in 3-pyrrolin-2-one Synthesis

Exploring the versatility of 5-sulfosalicylic acid dihydrate as catalyst in 3-pyrrolin-2-one Synthesis

We have developed a one-pot, four-component synthetic approach utilizing 5-sulfosalicylic acid dihydrate (5-SSA.2H2O) as an organocatalyst, enabling the synthesis of polyfunctional 3-pyrrolin-2-one molecules by employing dialkylacetylenedicarboxylate, amines, and either formaldehyde or aromatic aldehydes at room temperature. This approach presents numerous notable benefits such as shorter reaction time, simple and eco-friendly procedure, excellent yield, broad applicability across various substrates, and the use of a cost-effective, easily accessible and biodegradable catalyst. The structures of the 3-pyrrolin-2-one molecules were confirmed using techniques such as FTIR, 1HNMR, 13CNMR and HRMS. Overall, this study demonstrates a promising method for producing environmentally friendly polyfunctional 3-pyrrolin-2-one efficiently and smoothly at ambient temperature.

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来源期刊
CiteScore
5.70
自引率
18.20%
发文量
229
审稿时长
2.6 months
期刊介绍: Research on Chemical Intermediates publishes current research articles and concise dynamic reviews on the properties, structures and reactivities of intermediate species in all the various domains of chemistry. The journal also contains articles in related disciplines such as spectroscopy, molecular biology and biochemistry, atmospheric and environmental sciences, catalysis, photochemistry and photophysics. In addition, special issues dedicated to specific topics in the field are regularly published.
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