{"title":"BMPER 调节动脉对流量的适应性","authors":"Siyu Tian, Paul C. Evans","doi":"10.1038/s44161-024-00506-z","DOIUrl":null,"url":null,"abstract":"In response to high fluid shear stress, KLF2-mediated induction of the BMP inhibitor BMPER improves outward arterial remodeling. This knowledge is translated into a preclinical model showing that BMP9 and BMP10 neutralizing antibodies enhance flow recovery and arterialization in ischemia in diabetic mice.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"3 7","pages":"777-779"},"PeriodicalIF":9.4000,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"BMPER regulates arterial adaptation to flow\",\"authors\":\"Siyu Tian, Paul C. Evans\",\"doi\":\"10.1038/s44161-024-00506-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In response to high fluid shear stress, KLF2-mediated induction of the BMP inhibitor BMPER improves outward arterial remodeling. This knowledge is translated into a preclinical model showing that BMP9 and BMP10 neutralizing antibodies enhance flow recovery and arterialization in ischemia in diabetic mice.\",\"PeriodicalId\":74245,\"journal\":{\"name\":\"Nature cardiovascular research\",\"volume\":\"3 7\",\"pages\":\"777-779\"},\"PeriodicalIF\":9.4000,\"publicationDate\":\"2024-07-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature cardiovascular research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s44161-024-00506-z\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature cardiovascular research","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44161-024-00506-z","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
In response to high fluid shear stress, KLF2-mediated induction of the BMP inhibitor BMPER improves outward arterial remodeling. This knowledge is translated into a preclinical model showing that BMP9 and BMP10 neutralizing antibodies enhance flow recovery and arterialization in ischemia in diabetic mice.
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