{"title":"德斯梅尔膜脱落症中重力驱动的泪液流动和药物输送建模","authors":"","doi":"10.1016/j.aej.2024.07.019","DOIUrl":null,"url":null,"abstract":"<div><p>Topical medications are common initial treatments for Descemet’s membrane detachment (DMD). It is crucial to understand the aqueous humour (AH) flow and drug transport to facilitate the DMD treatment. This paper presents a mathematical model to analyse AH flow and drug transport in the anterior of the human eye considering gravity orientation effects. Utilizing the finite element method, the model couples AH flow dynamics, temperature-induced buoyancy, and drug transport by convection-diffusion. COMSOL Multiphysics is used to simulate the spatial-temporal distribution of AH and drugs delivery. The findings indicate that the eye positioning influences the directional flow of AH, due to temperature differences, and impacts the delivery of drug concentrations. It is also discovered that eye drops diffuse faster due to tear turnover in the eye yet more eye ointment is delivered as it has a longer contact time in the cornea. By understanding the AH flow and transport process, this proposed model may offer appropriate guidelines for optimizing DMD treatment under various forms of topical drugs and eye positions.</p></div>","PeriodicalId":7484,"journal":{"name":"alexandria engineering journal","volume":null,"pages":null},"PeriodicalIF":6.2000,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1110016824007403/pdfft?md5=c3ed4aefe4d2b6e42441d4b7f30bd3a6&pid=1-s2.0-S1110016824007403-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Modelling gravity-driven aqueous humour flow and drug delivery in Descemet’s membrane detachment\",\"authors\":\"\",\"doi\":\"10.1016/j.aej.2024.07.019\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Topical medications are common initial treatments for Descemet’s membrane detachment (DMD). It is crucial to understand the aqueous humour (AH) flow and drug transport to facilitate the DMD treatment. This paper presents a mathematical model to analyse AH flow and drug transport in the anterior of the human eye considering gravity orientation effects. Utilizing the finite element method, the model couples AH flow dynamics, temperature-induced buoyancy, and drug transport by convection-diffusion. COMSOL Multiphysics is used to simulate the spatial-temporal distribution of AH and drugs delivery. The findings indicate that the eye positioning influences the directional flow of AH, due to temperature differences, and impacts the delivery of drug concentrations. It is also discovered that eye drops diffuse faster due to tear turnover in the eye yet more eye ointment is delivered as it has a longer contact time in the cornea. By understanding the AH flow and transport process, this proposed model may offer appropriate guidelines for optimizing DMD treatment under various forms of topical drugs and eye positions.</p></div>\",\"PeriodicalId\":7484,\"journal\":{\"name\":\"alexandria engineering journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":6.2000,\"publicationDate\":\"2024-07-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1110016824007403/pdfft?md5=c3ed4aefe4d2b6e42441d4b7f30bd3a6&pid=1-s2.0-S1110016824007403-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"alexandria engineering journal\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1110016824007403\",\"RegionNum\":2,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"alexandria engineering journal","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1110016824007403","RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, MULTIDISCIPLINARY","Score":null,"Total":0}
Modelling gravity-driven aqueous humour flow and drug delivery in Descemet’s membrane detachment
Topical medications are common initial treatments for Descemet’s membrane detachment (DMD). It is crucial to understand the aqueous humour (AH) flow and drug transport to facilitate the DMD treatment. This paper presents a mathematical model to analyse AH flow and drug transport in the anterior of the human eye considering gravity orientation effects. Utilizing the finite element method, the model couples AH flow dynamics, temperature-induced buoyancy, and drug transport by convection-diffusion. COMSOL Multiphysics is used to simulate the spatial-temporal distribution of AH and drugs delivery. The findings indicate that the eye positioning influences the directional flow of AH, due to temperature differences, and impacts the delivery of drug concentrations. It is also discovered that eye drops diffuse faster due to tear turnover in the eye yet more eye ointment is delivered as it has a longer contact time in the cornea. By understanding the AH flow and transport process, this proposed model may offer appropriate guidelines for optimizing DMD treatment under various forms of topical drugs and eye positions.
期刊介绍:
Alexandria Engineering Journal is an international journal devoted to publishing high quality papers in the field of engineering and applied science. Alexandria Engineering Journal is cited in the Engineering Information Services (EIS) and the Chemical Abstracts (CA). The papers published in Alexandria Engineering Journal are grouped into five sections, according to the following classification:
• Mechanical, Production, Marine and Textile Engineering
• Electrical Engineering, Computer Science and Nuclear Engineering
• Civil and Architecture Engineering
• Chemical Engineering and Applied Sciences
• Environmental Engineering