DNA 结合蛋白-A：肾小管上皮细胞中的多功能工具

IF 14.8 1区医学 Q1 UROLOGY & NEPHROLOGY

Kidney international Pub Date : 2024-07-18 DOI:10.1016/j.kint.2024.05.022

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引用次数: 0

摘要

急性肾损伤仍然与高发病率和高死亡率有关。Reichardt 等人研究了 DNA 结合蛋白-A（Ybx3）在缺血再灌注损伤诱发的急性肾损伤中的作用，发现缺乏 Ybx3 的小鼠线粒体功能发生改变，抗氧化活性增强，从而对缺血再灌注损伤-急性肾损伤具有更强的抵抗力。这项研究强调了DNA结合蛋白-A这种多层面蛋白的新作用，它有可能被用于治疗。

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DNA-binding protein-A: a multitool in tubular epithelial cells

Acute kidney injury is still associated with high morbidity and mortality. Reichardt et al. investigated DNA-binding protein-A (Ybx3) in acute kidney injury induced by ischemia-reperfusion injury and found that mice lacking Ybx3 have altered mitochondrial function and increased antioxidant activity, making them more resistant to ischemia-reperfusion injury–acute kidney injury. The study highlights a new role of the multifaceted protein DNA-binding protein-A, which could be potentially therapeutically exploited.

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来源期刊

Kidney international 医学-泌尿学与肾脏学

CiteScore

23.30

自引率

3.10%

发文量

490

审稿时长

3-6 weeks

期刊介绍： Kidney International (KI), the official journal of the International Society of Nephrology, is led by Dr. Pierre Ronco (Paris, France) and stands as one of nephrology's most cited and esteemed publications worldwide. KI provides exceptional benefits for both readers and authors, featuring highly cited original articles, focused reviews, cutting-edge imaging techniques, and lively discussions on controversial topics. The journal is dedicated to kidney research, serving researchers, clinical investigators, and practicing nephrologists.