乳酸盐：慢性肾脏病进展过程中新陈代谢与炎症之间缺失的一环？

IF 14.8 1区医学 Q1 UROLOGY & NEPHROLOGY

Kidney international Pub Date : 2024-07-18 DOI:10.1016/j.kint.2024.05.016

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引用次数: 0

摘要

肾小管上皮细胞中糖酵解的持续增强与慢性肾脏病的进展有关，尽管其潜在机制在很大程度上还不清楚。在本期《国际肾脏》杂志上，Wang 等人报告说，糖酵解酶 6-磷酸果糖-2-激酶/果糖-2,6-二磷酸酶 3 通过乳酸盐积累增强组蛋白 H4 赖氨酸 12 乳酰化，从而在肾脏纤维化中发挥关键作用。这会增加核因子-κB 相关基因的转录，促进炎症和纤维化。抑制 6-磷酸果糖-2-激酶/果糖-2,6-二磷酸酶 3 可减轻这些影响，显示出治疗肾脏纤维化的潜力。

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Lactate: a missing link between metabolism and inflammation in CKD progression?

Persistent enhancement of glycolysis in kidney tubular epithelial cells has been linked to the progression of chronic kidney disease, although the underlying mechanisms are largely unknown. In this issue of Kidney International, Wang et al. report that the glycolytic enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 plays a crucial role in kidney fibrosis by enhancing histone H4 lysine 12 lactylation through lactate accumulation. This increases the transcription of nuclear factor-κB–related genes and promotes inflammation and fibrosis. Inhibiting 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 reduces these effects, indicating therapeutic potential for kidney fibrosis.

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来源期刊

Kidney international 医学-泌尿学与肾脏学

CiteScore

23.30

自引率

3.10%

发文量

490

审稿时长

3-6 weeks

期刊介绍： Kidney International (KI), the official journal of the International Society of Nephrology, is led by Dr. Pierre Ronco (Paris, France) and stands as one of nephrology's most cited and esteemed publications worldwide. KI provides exceptional benefits for both readers and authors, featuring highly cited original articles, focused reviews, cutting-edge imaging techniques, and lively discussions on controversial topics. The journal is dedicated to kidney research, serving researchers, clinical investigators, and practicing nephrologists.