微 RNA：Siglec 在癌症进展中的相互影响

IF 5.3 2区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Nano Materials Pub Date : 2024-07-18 DOI:10.1016/j.cbpa.2024.102502

D. Mustafov , M.S. Ahmad , A. Serrano , M. Braoudaki , S.S. Siddiqui

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引用次数: 0

摘要

肿瘤微环境中 Siglec 的异常表达与肿瘤恶性肿瘤有关，会影响肿瘤行为和患者生存。此外，与sialoglycans的接合会诱导掩蔽抗原识别，促进免疫逃避，从而凸显免疫功能失调。这就需要阐明它们在肿瘤进展过程中的表达谱。微RNA（miRNA）介导的靶向是进一步阐明Siglec潜力和临床相关性的一种新方法。尽管 miRNA 在 Siglec 表达中的活性仍然有限，但我们重点介绍了目前详细描述 miRNA：Siglec 在肿瘤中相互作用的文献，并为针对 Siglec/麸酸轴的可能诊断和治疗策略提供了见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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MicroRNA:Siglec crosstalk in cancer progression

Aberrant Siglec expression in the tumour microenvironment has been implicated in tumour malignancies and can impact tumour behaviour and patient survival. Further to this, engagement with sialoglycans induces masked antigen recognition and promotes immune evasion, highlighting deregulated immune function. This necessitates the elucidation of their expression profiles in tumour progression. MicroRNAs (miRNAs) mediated targeting represents a novel approach to further elucidate Siglec potential and clinical relevance. Although miRNA activity in Siglec expression remains limited, we highlight current literature detailing miRNA:Siglec interactions within the tumour landscape and provide insights for possible diagnostic and therapeutic strategies in targeting the Siglec/sialic acid axis.

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来源期刊

ACS Applied Nano Materials Multiple-

CiteScore

8.30

自引率

3.40%

发文量

1601

期刊介绍： ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.