中国老年人抑郁症状与认知障碍风险之间的性别差异

IF 2.2 4区 医学 Q1 NURSING
Xueyu Wu , Na Zhang , Jianqian Chao , Yiting Liu , Bowen Zhang
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引用次数: 0

摘要

研究背景许多研究关注抑郁症状与认知障碍之间的关系,但这种关系中的性别差异尚不明确,尤其是在中国老年人中。因此,本研究基于对中国老年人群的调查,探讨抑郁症状与认知障碍风险之间是否存在性别差异。研究设计这是一项横断面研究。方法我们从2018年CLHLS数据库中筛选了9678名65至105岁的老年人。采用10项流行病学研究中心抑郁量表(CESD-10)和迷你精神状态检查(MMSE)分别测量抑郁症状和认知能力。结果 在9678名参与者中,4719人(48.8%)为男性。严重抑郁症状与认知障碍之间的关系在老年男性中更为明显(男性 × 严重抑郁症状:OR = 2.71,95%CI = 1.07-6.92,p = 0.037)。与无抑郁症状相比,男性出现严重抑郁症状的认知障碍风险几乎高出五倍(OR = 4.84,95 % CI = 2.26-10.40,p < 0.001,而女性的 OR = 2.25,95 % CI = 1.27-3.96,p = 0.005)。在十种抑郁症状与认知障碍的关系中,性别差异也有所体现:感到孤独的男性更容易出现认知障碍(OR = 1.24,95 % CI = 1.06-1.47,p = 0.010),而睡眠质量差的女性更容易出现认知障碍(OR = 1.42,95 % CI = 1.16-1.74,p = 0.001)。我们的研究表明,减少孤独感有助于预防老年男性的认知障碍,而改善睡眠质量则有助于提高老年女性的认知功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sex-specific in the association between depressive symptoms and risk of cognitive impairment in Chinese older adults

Background

Many studies have focused on the relationship between depressive symptoms and cognitive impairment, but gender differences in this relationship are unclear, especially among Chinese older adults. Therefore, this study explores whether there are gender differences between depressive symptoms and risk of cognitive impairment based on a survey of a Chinese older adult population.

Study design

This is a cross-sectional study.

Method

We screened 9678 older adults aged 65 to 105 from the 2018 CLHLS database. The 10-item Center for Epidemiological Studies Depression Scale (CESD-10) and Mini-Mental State Examination (MMSE) were utilized for measuring depressive symptoms and cognitive performance, respectively. Logistic regressions and restricted cubic spline were applied to investigate the relationship between depressive symptoms and cognitive impairment.

Results

Of the 9678 participants, 4719 (48.8 %) were men. The association between severe depressive symptoms and cognitive impairment was more pronounced in older men (male × severe depressive symptoms: OR = 2.71, 95%CI = 1.07–6.92, p = 0.037). Compared with no depressive symptoms, severe depressive symptoms were associated with an almost five times greater risk of cognitive impairment in men (OR = 4.84, 95 % CI = 2.26–10.40, p < 0.001, compared to OR = 2.25, 95 % CI = 1.27–3.96, p = 0.005 in women). Gender differences were demonstrated in the association of individual ten depressive symptoms with cognitive impairment: men who felt lonely were more likely to have cognitive impairment (OR = 1.24, 95 % CI = 1.06–1.47, p = 0.010), while women who slept poorly were more likely to have cognitive impairment (OR = 1.42, 95 % CI = 1.16–1.74, p = 0.001).

Conclusion

Results indicate a stronger association between severe depressive symptoms and cognitive impairment among older Chinese males. Our study suggests that reducing loneliness can help prevent cognitive impairment in older men, and improving sleep quality can help improve cognitive function in older women.

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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
131
审稿时长
160 days
期刊介绍: Archives of Psychiatric Nursing disseminates original, peer-reviewed research that is of interest to psychiatric and mental health care nurses. The field is considered in its broadest perspective, including theory, practice and research applications related to all ages, special populations, settings, and interdisciplinary collaborations in both the public and private sectors. Through critical study, expositions, and review of practice, Archives of Psychiatric Nursing is a medium for clinical scholarship to provide theoretical linkages among diverse areas of practice.
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