一个有趣的替卡格雷诱发长 QTc 的病例系列

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE
Alireza Farzaei , Entezar Mehrabi Nasab , Yaser Jenab , Alireza Amirzadegan , Alireza Khodayari Javazm , Mokhtar Eisvand , Fateme Hajzeinolabedini , Ali Bozorgi
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引用次数: 0

摘要

本系列病例探讨了三名接受经皮冠状动脉介入治疗(PCI)的患者在使用替卡格雷治疗时出现 QT 间期延长的情况。第一例是一名女性患者,因胸痛接受了 Xience 支架治疗。第二例是一名男性患者,他接受了两个 Xience 支架治疗。第三个病例是一名患有 LAD 狭窄的男性患者。这三位患者都接受了替卡格雷治疗,心电图(ECG)显示 QTc 间期延长,在改用氯吡格雷治疗后症状得到缓解。迄今为止,文献中尚未充分论及替卡格雷对 QT 间期延长的潜在影响。据推测,替卡格雷可阻断红细胞对腺苷的摄取,这可能是QTc延长的原因。本系列病例的结果表明,替卡格雷可能会延长 QTc 间期。因此,临床医生必须意识到这一之前未列入清单的副作用,并在密切监测患者病情的同时寻求其他药物来控制病情。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An interesting case series of ticagrelor induced long QTc

This case series explores three patients who underwent percutaneous coronary intervention (PCI) and experienced prolonged QT intervals under treatment with Ticagrelor. The first case was a female who presented with chest pain and received a Xience stent. The second case involved a male patient who received two Xience stents. The third case was that of a male patient with LAD stenosis. All three patients received Ticagrelor and exhibited prolonged QTc intervals on their electrocardiograms (ECGs), which was resolved after switching to Clopidogrel. Thus far, the potential impact of Ticagrelor on QT prolongation has not been adequately addressed in the literature. It is hypothesized that Ticagrelor can block adenosine uptake by red blood cells, which may explain QTc prolongation. The results of this case series indicate that Ticagrelor may prolong QTc intervals. Consequently, it is imperative that clinicians are aware of this previously unlisted side effect and that patients are closely monitored while seeking alternative medications to manage the condition.

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