{"title":"秘鲁艾滋病毒感染者和非艾滋病毒感染者中猴痘的流行病学和临床特征：一项全国性观察研究","authors":"Max Carlos Ramírez-Soto , Hugo Arroyo-Hernández","doi":"10.1016/j.jiph.2024.102494","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>In Latin America, Peru has the second highest number of cases of monkeypox (Mpox), of which more than 50 % are Human Immunodeficiency Virus (HIV)-positive. Here, we compared the epidemiological and clinical characteristics of Mpox between people with and without HIV in Peru.</p></div><div><h3>Methods</h3><p>We conducted a national retrospective study using data on confirmed cases of Mpox reported by the Peruvian National Surveillance System from 15 June 2022 to 31 December 2023.</p></div><div><h3>Results</h3><p>A total of 3561 confirmed cases of Mpox were included. Of these, 2123 (60 %) patients were people living with HIV (PLWH), with increased odds for those aged 30 years or older, homosexual (adjusted odds ratio [aOR] 8.58 [6.95–10.59], p<0.0001), bisexual (aOR=4.44 [3.46–5.69], p<0.0001), sex workers (aOR=2.24 [1.07–4.68], p=0.032), people with a history of syphilis (aOR=2.07 [1.66–2.58], p<0.001), and hospitalized (aOR=3.08 [2.03–4.68], p<0.001). PLWH were more likely to have proctitis (aOR=1.73 [1.26–2.37], p=0.001). The overall mortality was 20 of 3561 (0.56 %). Among PLWH and Mpox, more deaths occurred in hospitalized (p<0.001) and non-ART (p<0.001) individuals.</p></div><div><h3>Conclusion</h3><p>Our findings highlight that HIV infection among Mpox cases in Peru is associated with high-risk sexual behaviour and a high likelihood of hospitalization.</p></div>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"17 8","pages":"Article 102494"},"PeriodicalIF":4.7000,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1876034124002284/pdfft?md5=f76920b8c3c8e6ca3cb5b5f5ac7bcfcf&pid=1-s2.0-S1876034124002284-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Epidemiological and clinical characteristics of monkeypox among people with and without HIV in Peru: a national observational study\",\"authors\":\"Max Carlos Ramírez-Soto , Hugo Arroyo-Hernández\",\"doi\":\"10.1016/j.jiph.2024.102494\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>In Latin America, Peru has the second highest number of cases of monkeypox (Mpox), of which more than 50 % are Human Immunodeficiency Virus (HIV)-positive. Here, we compared the epidemiological and clinical characteristics of Mpox between people with and without HIV in Peru.</p></div><div><h3>Methods</h3><p>We conducted a national retrospective study using data on confirmed cases of Mpox reported by the Peruvian National Surveillance System from 15 June 2022 to 31 December 2023.</p></div><div><h3>Results</h3><p>A total of 3561 confirmed cases of Mpox were included. Of these, 2123 (60 %) patients were people living with HIV (PLWH), with increased odds for those aged 30 years or older, homosexual (adjusted odds ratio [aOR] 8.58 [6.95–10.59], p<0.0001), bisexual (aOR=4.44 [3.46–5.69], p<0.0001), sex workers (aOR=2.24 [1.07–4.68], p=0.032), people with a history of syphilis (aOR=2.07 [1.66–2.58], p<0.001), and hospitalized (aOR=3.08 [2.03–4.68], p<0.001). PLWH were more likely to have proctitis (aOR=1.73 [1.26–2.37], p=0.001). The overall mortality was 20 of 3561 (0.56 %). Among PLWH and Mpox, more deaths occurred in hospitalized (p<0.001) and non-ART (p<0.001) individuals.</p></div><div><h3>Conclusion</h3><p>Our findings highlight that HIV infection among Mpox cases in Peru is associated with high-risk sexual behaviour and a high likelihood of hospitalization.</p></div>\",\"PeriodicalId\":16087,\"journal\":{\"name\":\"Journal of Infection and Public Health\",\"volume\":\"17 8\",\"pages\":\"Article 102494\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2024-07-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1876034124002284/pdfft?md5=f76920b8c3c8e6ca3cb5b5f5ac7bcfcf&pid=1-s2.0-S1876034124002284-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Infection and Public Health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1876034124002284\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Infection and Public Health","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1876034124002284","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Epidemiological and clinical characteristics of monkeypox among people with and without HIV in Peru: a national observational study
Background
In Latin America, Peru has the second highest number of cases of monkeypox (Mpox), of which more than 50 % are Human Immunodeficiency Virus (HIV)-positive. Here, we compared the epidemiological and clinical characteristics of Mpox between people with and without HIV in Peru.
Methods
We conducted a national retrospective study using data on confirmed cases of Mpox reported by the Peruvian National Surveillance System from 15 June 2022 to 31 December 2023.
Results
A total of 3561 confirmed cases of Mpox were included. Of these, 2123 (60 %) patients were people living with HIV (PLWH), with increased odds for those aged 30 years or older, homosexual (adjusted odds ratio [aOR] 8.58 [6.95–10.59], p<0.0001), bisexual (aOR=4.44 [3.46–5.69], p<0.0001), sex workers (aOR=2.24 [1.07–4.68], p=0.032), people with a history of syphilis (aOR=2.07 [1.66–2.58], p<0.001), and hospitalized (aOR=3.08 [2.03–4.68], p<0.001). PLWH were more likely to have proctitis (aOR=1.73 [1.26–2.37], p=0.001). The overall mortality was 20 of 3561 (0.56 %). Among PLWH and Mpox, more deaths occurred in hospitalized (p<0.001) and non-ART (p<0.001) individuals.
Conclusion
Our findings highlight that HIV infection among Mpox cases in Peru is associated with high-risk sexual behaviour and a high likelihood of hospitalization.
期刊介绍：
The Journal of Infection and Public Health, first official journal of the Saudi Arabian Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences and the Saudi Association for Public Health, aims to be the foremost scientific, peer-reviewed journal encompassing infection prevention and control, microbiology, infectious diseases, public health and the application of healthcare epidemiology to the evaluation of health outcomes. The point of view of the journal is that infection and public health are closely intertwined and that advances in one area will have positive consequences on the other.
The journal will be useful to all health professionals who are partners in the management of patients with communicable diseases, keeping them up to date. The journal is proud to have an international and diverse editorial board that will assist and facilitate the publication of articles that reflect a global view on infection control and public health, as well as emphasizing our focus on supporting the needs of public health practitioners.
It is our aim to improve healthcare by reducing risk of infection and related adverse outcomes by critical review, selection, and dissemination of new and relevant information in the field of infection control, public health and infectious diseases in all healthcare settings and the community.
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