PLCβ 的新亮点！

IF 6.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Chemical Biology Pub Date : 2024-07-18 DOI:10.1016/j.chembiol.2024.06.007

Sithurandi Ubeysinghe , Waruna Thotamune , Ajith Karunarathne

引用次数: 0

摘要

在本期《细胞化学生物学》（Cell Chemical Biology）杂志上，Kim 等人1 提出了一种新型光遗传学工具--opto-PLCβ，它能以光学方式控制 PLCβ 信号传导。除了在细胞中诱发 PIP2 水解和下游信号传导外，opto-PLCβ 还能探究 PLCβ 信号传导对小鼠杏仁核突触可塑性和恐惧学习的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A new light on PLCβ!

In this issue of Cell Chemical Biology, Kim et al.¹ present a novel optogenetic tool, opto-PLCβ, to control PLCβ signaling optically. In addition to eliciting PIP2 hydrolysis and downstream signaling in cells, opto-PLCβ also enabled probing the impact of PLCβ signaling on amygdala synaptic plasticity and fear learning in mice.

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来源期刊

Cell Chemical Biology Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

14.70

自引率

2.30%

发文量

143

期刊介绍： Cell Chemical Biology, a Cell Press journal established in 1994 as Chemistry & Biology, focuses on publishing crucial advances in chemical biology research with broad appeal to our diverse community, spanning basic scientists to clinicians. Pioneering investigations at the chemistry-biology interface, the journal fosters collaboration between these disciplines. We encourage submissions providing significant conceptual advancements of broad interest across chemical, biological, clinical, and related fields. Particularly sought are articles utilizing chemical tools to perturb, visualize, and measure biological systems, offering unique insights into molecular mechanisms, disease biology, and therapeutics.