大流行相关压力与高危青少年 COVID-19 期间内化症状之间关系的大脑形态宏观结构调节器。

IF 8.3 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces Pub Date : 2024-11-01 DOI:10.1016/j.bpsc.2024.07.002

McKinley Pawlak , Jennifer Kemp , Signe Bray , Sneha Chenji , Melanie Noel , Kathryn A. Birnie , Frank P. MacMaster , Jillian Vinall Miller , Daniel C. Kopala-Sibley

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引用次数: 0

摘要

背景：根据 "因人因环境 "模型，个体特质的差异可能会缓和压力因素与心理病理学发展之间的关联；然而，文献中的研究结果并不一致，很少有文献研究青少年的大脑结构是压力对青少年内化症状影响的调节因素。COVID-19 大流行为研究压力、大脑结构和心理病理学之间的关联提供了一个独特的机会。考虑到大脑皮层形态与青少年抑郁和焦虑之间的联系，本研究调查了大脑皮层形态是否会调节 COVID-19 大流行所带来的压力与家族性高危青少年内化症状发展之间的关系：在 COVID-19 大流行之前，72 名青少年（27 岁）完成了抑郁和焦虑症状的测量，并接受了磁共振成像检查。采集 T1 加权图像以评估皮质厚度和表面积。在COVID-19被宣布为全球性流行病约6-8个月后，青少年报告了他们的抑郁和焦虑症状以及与流行病有关的压力：结果：在对大流行前的抑郁症状、焦虑症状和压力进行调整后，大流行相关压力的增加与抑郁症状的增加有关，但与焦虑症状无关。这种关系受前扣带回皮质厚度和表面积以及内侧眶额皮质厚度的调节，因此只有在这些区域皮质表面积较低而皮质厚度较高的青少年中，压力增加才与抑郁和焦虑症状的增加有关：研究结果进一步加深了我们对压力与内化症状之间的神经脆弱性的理解，尤其是在COVID-19大流行期间。

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Macrostructural Brain Morphology as Moderator of the Relationship Between Pandemic-Related Stress and Internalizing Symptomology During COVID-19 in High-Risk Adolescents

Background

According to person-by-environment models, individual differences in traits may moderate the association between stressors and the development of psychopathology; however, findings in the literature have been inconsistent and little literature has examined adolescent brain structure as a moderator of the effects of stress on adolescent internalizing symptoms. The COVID-19 pandemic presented a unique opportunity to examine the associations between stress, brain structure, and psychopathology. Given links of cortical morphology with adolescent depression and anxiety, the current study investigated whether cortical morphology moderated the relationship between stress from the COVID-19 pandemic and the development of internalizing symptoms in familial high-risk adolescents.

Methods

Prior to the COVID-19 pandemic, 72 adolescents (27 male) completed a measure of depressive and anxiety symptoms and underwent magnetic resonance imaging. T1-weighted images were acquired to assess cortical thickness and surface area. Approximately 6 to 8 months after COVID-19 was declared a global pandemic, adolescents reported their depressive and anxiety symptoms and pandemic-related stress.

Results

Adjusting for pre-pandemic depressive and anxiety symptoms and stress, increased pandemic-related stress was associated with increased depressive but not anxiety symptoms. This relationship was moderated by cortical thickness and surface area in the anterior cingulate and cortical thickness in the medial orbitofrontal cortex such that increased stress was only associated with increased depressive and anxiety symptoms among adolescents with lower cortical surface area and higher cortical thickness in these regions.

Conclusions

Results further our understanding of neural vulnerabilities to the associations between stress and internalizing symptoms in general and during the COVID-19 pandemic in particular.

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来源期刊

ACS Applied Materials & Interfaces 工程技术-材料科学：综合

CiteScore

16.00

自引率

6.30%

发文量

4978

审稿时长

1.8 months

期刊介绍： ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.