小儿急性肾损伤后的长期肾脏预后。

IF 10.3 1区医学 Q1 UROLOGY & NEPHROLOGY

Journal of The American Society of Nephrology Pub Date : 2024-11-01 Epub Date: 2024-07-17 DOI:10.1681/ASN.0000000000000445

Cal H Robinson, Nivethika Jeyakumar, Bin Luo, David Askenazi, Akash Deep, Amit X Garg, Stuart Goldstein, Jason H Greenberg, Cherry Mammen, Danielle M Nash, Rulan S Parekh, Samuel A Silver, Lehana Thabane, Ron Wald, Michael Zappitelli, Rahul Chanchlani

引用次数: 0

摘要

背景：急性肾损伤（AKI）在住院儿童中很常见。接受急性肾脏替代治疗（KRT）的小儿 AKI 与长期慢性肾脏疾病（CKD）、高血压和死亡有关。我们旨在确定未接受急性肾脏替代治疗的儿童在发生 AKI 后的预后，因为这些预后仍不确定：方法：对加拿大安大略省 1996-2020 年间所有未接受急性 KRT 的 AKI 住院患儿（0-18 岁）进行回顾性队列研究。曾接受过 KRT、CKD 或 AKI 的儿童不包括在内。根据年龄、新生儿状况、性别、入住重症监护室、心脏手术、恶性肿瘤、高血压、住院时间和 AKI 倾向评分，将病例与最多四名无 AKI 的住院对比者进行配对。对患者进行随访，直至死亡、移居他省或 2021 年 3 月剔除。主要结果是长期主要肾脏不良事件（MAKE-LT；全因死亡率、长期KRT或事件性CKD的复合结果）：我们将 4,173 名儿科 AKI 幸存者与 16,337 名住院对比者进行了配对。经过倾向评分匹配后，基线协变量非常均衡。在中位 9.7 年的随访期间，18% 的 AKI 幸存者与 5% 的住院对比者相比，患 MAKE-LT （危险比 [HR] 4.0，95% 置信区间 [CI] 3.6-4.4）。AKI 幸存者接受长期 KRT 的比例更高（2% vs. 5%）：与住院的比较者相比，未进行急性 KRT 的 AKI 幸存儿童患慢性肾脏病、长期 KRT、高血压和继发性 AKI 的长期风险更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Long-Term Kidney Outcomes after Pediatric Acute Kidney Injury.

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来源期刊

Journal of The American Society of Nephrology 医学-泌尿学与肾脏学

CiteScore

22.40

自引率

2.90%

发文量

492

审稿时长

3-8 weeks

期刊介绍： The Journal of the American Society of Nephrology (JASN) stands as the preeminent kidney journal globally, offering an exceptional synthesis of cutting-edge basic research, clinical epidemiology, meta-analysis, and relevant editorial content. Representing a comprehensive resource, JASN encompasses clinical research, editorials distilling key findings, perspectives, and timely reviews. Editorials are skillfully crafted to elucidate the essential insights of the parent article, while JASN actively encourages the submission of Letters to the Editor discussing recently published articles. The reviews featured in JASN are consistently erudite and comprehensive, providing thorough coverage of respective fields. Since its inception in July 1990, JASN has been a monthly publication. JASN publishes original research reports and editorial content across a spectrum of basic and clinical science relevant to the broad discipline of nephrology. Topics covered include renal cell biology, developmental biology of the kidney, genetics of kidney disease, cell and transport physiology, hemodynamics and vascular regulation, mechanisms of blood pressure regulation, renal immunology, kidney pathology, pathophysiology of kidney diseases, nephrolithiasis, clinical nephrology (including dialysis and transplantation), and hypertension. Furthermore, articles addressing healthcare policy and care delivery issues relevant to nephrology are warmly welcomed.