文献综述:外部射频电磁场对癌症的潜在非热分子效应。

IF 3 3区 医学 Q2 ONCOLOGY
International Journal of Hyperthermia Pub Date : 2024-01-01 Epub Date: 2024-07-17 DOI:10.1080/02656736.2024.2379992
Anna Dieper, Stephan Scheidegger, Rudolf M Füchslin, Paraskevi D Veltsista, Ulrike Stein, Mathias Weyland, Dominik Gerster, Marcus Beck, Olof Bengtsson, Daniel Zips, Pirus Ghadjar
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引用次数: 0

摘要

导言:科学界一直在讨论,射频(RF)-热疗诱导的抗癌效应可能不仅仅归因于肿瘤部位随后的温度升高,还可能归因于非温度诱导效应。然而,这些潜在的非射频热效应背后的确切分子机制在很大程度上仍然难以捉摸,从而限制了它们的治疗靶向性:因此,我们旨在概述目前有关射频电磁场(RF-EMF)对癌细胞的潜在非温度诱导分子效应的文献:本文献综述遵循 PRISMA 指南。为此,我们于 2024 年 3 月 23 日在 MEDLINE(PubMed)和 Scopus(Elsevier)上进行了以 MeSH 术语定义的文献检索。其中的基本标准包括射频电磁场源的连续波性质(3 kHz - 300 GHz)、试验中的温控环境保障以及试验的临床前性质:结果:对本综述所处理数据的分析表明,各种频率的射频-电磁场辐射似乎都能诱发显著的非温度诱导抗癌效应。这些效应包括有丝分裂停滞、生长抑制以及以自噬和细胞凋亡形式出现的癌细胞死亡,而且似乎主要是癌细胞独有的效应。研究发现了射频-电磁场辐射可能产生抗癌作用的几种细胞机制。在这些机制中,通过审查收录的文献,我们确定了射频-电磁场诱导的离子通道激活、基因表达改变、膜电位改变、膜振荡和漂白,以及细胞骨架结构和细胞形态的变化:现有文献表明,射频-电磁场疗法具有尚未开发的治疗潜力,它可能有助于通过生物电和电子机械分子机制破坏癌细胞,同时最大限度地减少对健康组织细胞的不利影响。进一步的研究势在必行,以明确证实非热电磁场效应,并确定针对特定癌症类型的最佳射频电磁场频率、场强和照射间隔。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Literature review: potential non-thermal molecular effects of external radiofrequency electromagnetic fields on cancer.

Introduction: There is an ongoing scientific discussion, that anti-cancer effects induced by radiofrequency (RF)-hyperthermia might not be solely attributable to subsequent temperature elevations at the tumor site but also to non-temperature-induced effects. The exact molecular mechanisms behind said potential non-thermal RF effects remain largely elusive, however, limiting their therapeutical targetability.

Objective: Therefore, we aim to provide an overview of the current literature on potential non-temperature-induced molecular effects within cancer cells in response to RF-electromagnetic fields (RF-EMF).

Material and methods: This literature review was conducted following the PRISMA guidelines. For this purpose, a MeSH-term-defined literature search on MEDLINE (PubMed) and Scopus (Elsevier) was conducted on March 23rd, 2024. Essential criteria herein included the continuous wave RF-EMF nature (3 kHz - 300 GHz) of the source, the securing of temperature-controlled circumstances within the trials, and the preclinical nature of the trials.

Results: Analysis of the data processed in this review suggests that RF-EMF radiation of various frequencies seems to be able to induce significant non-temperature-induced anti-cancer effects. These effects span from mitotic arrest and growth inhibition to cancer cell death in the form of autophagy and apoptosis and appear to be mostly exclusive to cancer cells. Several cellular mechanisms were identified through which RF-EMF radiation potentially imposes its anti-cancer effects. Among those, by reviewing the included publications, we identified RF-EMF-induced ion channel activation, altered gene expression, altered membrane potentials, membrane oscillations, and blebbing, as well as changes in cytoskeletal structure and cell morphology.

Conclusion: The existent literature points toward a yet untapped therapeutic potential of RF-EMF treatment, which might aid in damaging cancer cells through bio-electrical and electro-mechanical molecular mechanisms while minimizing adverse effects on healthy tissue cells. Further research is imperative to definitively confirm non-thermal EMF effects as well as to determine optimal cancer-type-specific RF-EMF frequencies, field intensities, and exposure intervals.

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来源期刊
CiteScore
5.90
自引率
12.90%
发文量
153
审稿时长
6-12 weeks
期刊介绍: The International Journal of Hyperthermia
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