[18F]-florbetaben PET/CT 对心脏 AL 淀粉样变性病很敏感。

IF 4.4 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

European Journal of Clinical Investigation Pub Date : 2024-07-17 DOI:10.1111/eci.14270

Raffaella Cassano Cassano, Dario Genovesi, Giuseppe Vergaro, Assuero Giorgetti, Alberto Aimo, Maria Livia Del Giudice, Sara Galimberti, Michele Emdin, Gabriele Buda

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引用次数: 0

摘要

AL 和 ATTR 淀粉样变性之间的鉴别诊断通常比较困难。关于 ATTR，敏感的诊断工具--二膦酸盐闪烁照相术已得到验证，但没有一种成像方法对 AL 的诊断同样准确。心脏超声和循环生物标志物可能会引起临床怀疑，但活检仍是诊断的唯一选择。我们的目的是在一组 33 例患者中探讨 18F-Florbetaben PET 相对于血液检测或脐周脂肪 (POF)、心脏、骨髓 (BM) 或其他组织活检的敏感性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

[18F]-florbetaben PET/CT is sensitive for cardiac AL amyloidosis

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[18F]-florbetaben PET/CT is sensitive for cardiac AL amyloidosis

Often differential diagnosis between AL and ATTR amyloidosis is difficult. Concerning ATTR, sensitive diagnostic tool, as diphosphonate scintigraphy, was validated, instead of no imaging approach is as accurate in AL. Cardiac ultrasound and circulating biomarkers may raise the clinical suspicion but biopsy remains the only option for diagnosis. We aimed to explore the sensitivity of 18F-Florbetaben PET respect to blood tests or periumbilical fat (POF), cardiac, bone marrow (BM) or other tissues biopsies in a cohort of 33 patients.

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来源期刊

European Journal of Clinical Investigation 医学-医学：内科

CiteScore

9.50

自引率

3.60%

发文量

192

审稿时长

1 months

期刊介绍： EJCI considers any original contribution from the most sophisticated basic molecular sciences to applied clinical and translational research and evidence-based medicine across a broad range of subspecialties. The EJCI publishes reports of high-quality research that pertain to the genetic, molecular, cellular, or physiological basis of human biology and disease, as well as research that addresses prevalence, diagnosis, course, treatment, and prevention of disease. We are primarily interested in studies directly pertinent to humans, but submission of robust in vitro and animal work is also encouraged. Interdisciplinary work and research using innovative methods and combinations of laboratory, clinical, and epidemiological methodologies and techniques is of great interest to the journal. Several categories of manuscripts (for detailed description see below) are considered: editorials, original articles (also including randomized clinical trials, systematic reviews and meta-analyses), reviews (narrative reviews), opinion articles (including debates, perspectives and commentaries); and letters to the Editor.