耐药性高血压实验研究进展。

IF 3.9 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE
Current Hypertension Reports Pub Date : 2024-12-01 Epub Date: 2024-07-18 DOI:10.1007/s11906-024-01315-2
Maria Claudia Irigoyen, Claudia Fetter, Kátia De Angelis
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引用次数: 0

摘要

综述的目的:难治性高血压(RH)对公共卫生构成重大挑战,导致死亡率、心血管事件和器官损伤增加。临床和实验研究都在以转化的方式追求更高的标准,以整合新的发现并证实假设。考虑到生殖健康的许多方面仍在研究之中,本综述旨在阐明有关生殖健康的实验研究取得的进展。本综述旨在强调实验研究在临床实践中的关键作用,并探讨未来的发展前景:必须强调实验模型的重要性,这主要是为了加深我们的理解:实验模型极大地促进了我们对 RH 潜在机制的理解,包括交感神经激活、内皮功能障碍和血管结构异常等因素。其次,用于评估治疗方法:动物模型在评估各种 RH 治疗方法的潜在有效性方面也发挥了至关重要的作用。这些方法既包括药物治疗方案,涉及既有药物或新型药物的组合,也包括非药物治疗方案,其中包括肾脏去神经支配等外科手术、气压感受器刺激器等医疗器械以及生活方式的改变。转化研究中最缺乏的部分是没有一个完善的动物模型可以完美地复制 RH。因此,必须考虑其他策略,包括模型组合。但显而易见的是,建立近似 RH 的动物模型有望为了解抗击或减缓 RH 全球进展所必需的基本机制和反应提供宝贵的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Advances on the Experimental Research in Resistant Hypertension.

Advances on the Experimental Research in Resistant Hypertension.

Purpose of review: Resistant Hypertension (RH) poses a significant public health challenge, contributing to increased mortality, cardiovascular events and organ damage. Both clinical and experimental research are striving for higher standards in a translational manner to integrate new findings and confirm hypotheses. Considering that many are the aspects of RH that are still under investigation, this review aims to shed light on the advances made in experimental research concerning RH. It seeks to underscore the pivotal role of experimental studies in shaping clinical practices and also explore future perspectives.

Recent findings: It is important to emphasize the significance of experimental models, primarily for advancing our understanding: experimental models have greatly contributed to our comprehension of the underlying mechanisms in RH, including factors like sympathetic activation, endothelial dysfunction and structural vessel abnormalities. Secondly, for assessing treatment approaches: animal models have also played a crucial role in evaluating the potential effectiveness of diverse treatment approaches for RH. These encompass both pharmacological options, involving combinations of established drugs or novel pharmaceuticals, and non-pharmacological alternatives, which include surgical procedures like renal denervation, medical devices like baroreceptor stimulators, and lifestyle modifications. The most lacking component in translational research is the fact that there is no well-established animal model that perfectly replicates RH. Consequently, alternative strategies, including the combination of models, must be considered. What remains clear is that the development of animal models closely mimicking RH holds the promise of providing valuable insights into the essential mechanisms and responses necessary to combat or slow the global progression of RH.

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来源期刊
Current Hypertension Reports
Current Hypertension Reports 医学-外周血管病
CiteScore
10.50
自引率
0.00%
发文量
65
审稿时长
6-12 weeks
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of hypertension. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antihypertensive therapies, associated metabolic disorders, and therapeutic trials. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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