Jakob F. B. Schwensen, Wolfgang Uter, Olivier Aerts, Tove Agner, Richard Brans, Magnus Bruze, Caterina Foti, Ana Maria Giménez-Arnau, Margarida Gonçalo, Cecilia Svedman, Luca Stingeni, Mark Wilkinson, Jeanne Duus Johansen, the European Environmental Contact Dermatitis Research Group
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This was followed by regulations of use with a total ban on leave-on (implemented in 2017) and reduced use concentrations in rinse-off cosmetics (2018).</p>\n </section>\n \n <section>\n \n <h3> Objective</h3>\n \n <p>To follow-up on the prevalence of contact allergy to MI and the related benzisothiazolinone (BIT) and octylisothiazolinone (OIT) in consecutively patch-tested patients in Europe.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A cross-sectional audit following the design of two previous audits on MI contact allergy from 1 May 2022 to 31 October 2022 included all patients patch tested with the European baseline series, including or supplemented with MI, BIT and OIT across 10 departments in eight European countries.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>A total of 2554 patients were consecutively patch tested with the three isothiazolinones during the study period. The prevalence of MI and BIT contact allergy was 2.9% (95% confidence interval [CI]: 2.3%–3.7%; range 1.1%–5.8%) and 3.1% (95% CI: 2.4%–3.9%; range 0.0%–6.6%), respectively; that of OIT was 0.7% (95% CI: 0.4%–1.1%; range 0%–3.2%). Rinse-off cosmetic (73.3%) and leave-on cosmetic products (13.3%) were still associated with eliciting allergic contact dermatitis to MI.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>We confirmed a positive impact of regulatory measures on the prevalence of MI contact allergy in Europe, which halved compared to 2015. However, our data suggest that consumers may still be exposed to older cosmetic products containing MI. BIT has superseded MI in causing contact allergy, despite not being allowed for use in cosmetic products.</p>\n </section>\n </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":null,"pages":null},"PeriodicalIF":4.8000,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Current frequency of contact allergy to isothiazolinones (methyl-, benz- and octylisothiazolinone) across Europe\",\"authors\":\"Jakob F. B. 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引用次数: 0
摘要
背景:2010 年代,由于在化妆品中使用甲基异噻唑啉酮(MI)作为防腐剂,整个欧洲的甲基异噻唑啉酮接触过敏病例急剧增加。随后,欧洲出台了全面禁止使用免洗型化妆品(2017 年实施)和降低冲洗型化妆品使用浓度(2018 年实施)的使用规定:目的:跟踪调查欧洲连续接受贴片测试的患者中对 MI 及相关的苯并异噻唑啉酮(BIT)和辛基异噻唑啉酮(OIT)接触过敏的发生率:方法:2022 年 5 月 1 日至 2022 年 10 月 31 日,按照前两次关于 MI 接触过敏的审计设计,对欧洲 8 个国家 10 个部门的所有患者进行了横断面审计,包括或补充使用 MI、BIT 和 OIT 的欧洲基线系列贴片测试:结果:在研究期间,共有 2554 名患者连续接受了三种异噻唑啉酮的贴敷测试。MI和BIT接触过敏的发病率分别为2.9%(95%置信区间[CI]:2.3%-3.7%;范围1.1%-5.8%)和3.1%(95%置信区间:2.4%-3.9%;范围0.0%-6.6%);OIT的发病率为0.7%(95%置信区间:0.4%-1.1%;范围0%-3.2%)。冲洗型化妆品(73.3%)和免洗型化妆品(13.3%)仍与引起 MI 过敏性接触性皮炎有关:我们证实了监管措施对欧洲 MI 接触性过敏发病率的积极影响,与 2015 年相比,发病率下降了一半。然而,我们的数据表明,消费者仍有可能接触到含有MI的旧化妆品。尽管不允许在化妆品中使用BIT,但BIT在引起接触过敏方面已经取代了MI。
Current frequency of contact allergy to isothiazolinones (methyl-, benz- and octylisothiazolinone) across Europe
Background
The use of methylisothiazolinone (MI) as a preservative in cosmetic products caused an alarming increase in MI contact allergy across Europe in the 2010s. This was followed by regulations of use with a total ban on leave-on (implemented in 2017) and reduced use concentrations in rinse-off cosmetics (2018).
Objective
To follow-up on the prevalence of contact allergy to MI and the related benzisothiazolinone (BIT) and octylisothiazolinone (OIT) in consecutively patch-tested patients in Europe.
Methods
A cross-sectional audit following the design of two previous audits on MI contact allergy from 1 May 2022 to 31 October 2022 included all patients patch tested with the European baseline series, including or supplemented with MI, BIT and OIT across 10 departments in eight European countries.
Results
A total of 2554 patients were consecutively patch tested with the three isothiazolinones during the study period. The prevalence of MI and BIT contact allergy was 2.9% (95% confidence interval [CI]: 2.3%–3.7%; range 1.1%–5.8%) and 3.1% (95% CI: 2.4%–3.9%; range 0.0%–6.6%), respectively; that of OIT was 0.7% (95% CI: 0.4%–1.1%; range 0%–3.2%). Rinse-off cosmetic (73.3%) and leave-on cosmetic products (13.3%) were still associated with eliciting allergic contact dermatitis to MI.
Conclusion
We confirmed a positive impact of regulatory measures on the prevalence of MI contact allergy in Europe, which halved compared to 2015. However, our data suggest that consumers may still be exposed to older cosmetic products containing MI. BIT has superseded MI in causing contact allergy, despite not being allowed for use in cosmetic products.
期刊介绍:
Contact Dermatitis is designed primarily as a journal for clinicians who are interested in various aspects of environmental dermatitis. This includes both allergic and irritant (toxic) types of contact dermatitis, occupational (industrial) dermatitis and consumers" dermatitis from such products as cosmetics and toiletries. The journal aims at promoting and maintaining communication among dermatologists, industrial physicians, allergists and clinical immunologists, as well as chemists and research workers involved in industry and the production of consumer goods. Papers are invited on clinical observations, diagnosis and methods of investigation of patients, therapeutic measures, organisation and legislation relating to the control of occupational and consumers".