基于锰复合物的磁共振成像制剂的进展：创新、设计策略和未来方向。

IF 6.5 2区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Discovery Today Pub Date : 2024-07-15 DOI:10.1016/j.drudis.2024.104101

Shubham Roy , Jingsi Gu , Wujiong Xia , Chao Mi , Bing Guo

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引用次数: 0

摘要

本综述重点介绍基于锰（Mn）复合物的磁共振成像（MRI）剂在不同疾病成像方面取得的进展。在此，我们强调锰的独特氧化还原特性，以提供创新的磁共振成像造影剂，包括小分子、纳米颗粒（NPs）、金属有机框架（MOFs）和聚合物混合物。本研究讨论了合理设计的各个方面，包括尺寸依赖性、形态调整、表面特性增强等，同时还讨论了现有的挑战和潜在的解决方案。本研究将启发和激励科学家重视磁共振成像引导的应用，并在未来几年取得临床成功。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Advancements in manganese complex-based MRI agents: Innovations, design strategies, and future directions

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Advancements in manganese complex-based MRI agents: Innovations, design strategies, and future directions

This review focuses on the advancements in manganese (Mn) complex-based magnetic resonance imaging (MRI) agents for imaging different diseases. Here we emphasize the unique redox properties of Mn to deliver innovative MRI contrast agents, including small molecules, nanoparticles (NPs), metal–organic frameworks (MOFs), and polymer hybrids. Aspects of their rational design have been discussed, including size dependence, morphology tuning, surface property enhancement, etc., while also discussing the existing challenges and potential solutions. The present work will inspire and motivate scientists to emphasize MRI-guided applications and bring clinical success in the coming years.

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来源期刊

Drug Discovery Today 医学-药学

CiteScore

14.80

自引率

2.70%

发文量

293

审稿时长

6 months

期刊介绍： Drug Discovery Today delivers informed and highly current reviews for the discovery community. The magazine addresses not only the rapid scientific developments in drug discovery associated technologies but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed. Features include comment by international experts, news and analysis of important developments, reviews of key scientific and strategic issues, overviews of recent progress in specific therapeutic areas and conference reports.