染色质状态和BACH2控制TH17细胞的功能异质性

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2024-07-17 DOI:10.1038/s41590-024-01904-y

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引用次数: 0

摘要

我们对 TH17 细胞进行了转录和染色质可及性分析，以区分调控致病性与非致病性 TH17 细胞亚群的途径。我们发现 TH17 细胞的功能异质性与 TH17 细胞和其他 CD4+ T 细胞状态之间共享的不同调控程序有关。BACH2被确定为TH17细胞介导的自身免疫的关键调控因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Chromatin state and BACH2 control TH17 cell functional heterogeneity

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Chromatin state and BACH2 control TH17 cell functional heterogeneity

We performed transcriptional and chromatin accessibility profiling of TH17 cells to distinguish the pathways that regulate pathogenic versus non-pathogenic TH17 cell subsets. We show that TH17 cell functional heterogeneity is linked to distinct regulatory programs that are shared between TH17 cells and other CD4+ T cell states. BACH2 was identified as a key regulator of TH17 cell-mediated autoimmunity.

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.