抗高血压药物治疗与血液透析中低血压的风险。

IF 8.5 1区 医学 Q1 UROLOGY & NEPHROLOGY
Carmine Zoccali, Giovanni Tripepi, Paola Carioni, Edouard L Fu, Friedo Dekker, Vianda Stel, Kitty J Jager, Francesca Mallamaci, Jeffrey L Hymes, Franklin W Maddux, Stefano Stuard
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引用次数: 0

摘要

背景:血液透析(HD)患者通常会服用降压药来控制高血压,而血液透析内低血压(IDH)是这些患者常见的并发症。我们调查了开始使用单药降压治疗的血液透析患者发生 IDH 的风险:该研究仿照随机临床试验的方式进行,研究对象为 4072 名在 2016 年 1 月至 2019 年 12 月期间开始接受降压药物治疗的 HD 患者。主要结果是在 HD 治疗期间发生 IDH。通过逆概率治疗加权(IPTW)对通用估计方程(GEE)分析进行了调整:结果:使用钙通道阻滞剂(CCB)与每人每年 7.4 例(95% CI:6.2-8.6)的 IDH 发生率相关。与使用钙通道阻滞剂相比,使用β和α-β阻滞剂与更高的IDH发病率密切相关(OR [95% CI] 2.27 [1.50-3.43])。与使用CCB相比,使用血管紧张素转换酶(ACE)抑制剂或血管紧张素II受体阻滞剂(OR [95% CI] 1.71 [1.14-2.57])和利尿剂(OR [95% CI] 1.52 [1.07-2.16])也与更高的IDH可能性相关:该研究表明,与使用CCB相比,使用β和α-β受体阻滞剂、ACE抑制剂或血管紧张素II受体阻滞剂以及利尿剂可能会增加HD患者罹患IDH的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antihypertensive Drug Treatment and the Risk for Intrahemodialysis Hypotension.
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来源期刊
CiteScore
12.20
自引率
3.10%
发文量
514
审稿时长
3-6 weeks
期刊介绍: The Clinical Journal of the American Society of Nephrology strives to establish itself as the foremost authority in communicating and influencing advances in clinical nephrology by (1) swiftly and effectively disseminating pivotal developments in clinical and translational research in nephrology, encompassing innovations in research methods and care delivery; (2) providing context for these advances in relation to future research directions and patient care; and (3) becoming a key voice on issues with potential implications for the clinical practice of nephrology, particularly within the United States. Original manuscript topics cover a range of areas, including Acid/Base and Electrolyte Disorders, Acute Kidney Injury and ICU Nephrology, Chronic Kidney Disease, Clinical Nephrology, Cystic Kidney Disease, Diabetes and the Kidney, Genetics, Geriatric and Palliative Nephrology, Glomerular and Tubulointerstitial Diseases, Hypertension, Maintenance Dialysis, Mineral Metabolism, Nephrolithiasis, and Transplantation.
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