原发性醛固酮增多症患者血压达标时间与心血管综合后果之间的关系：一项回顾性病例研究。

IF 3 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Endocrine Pub Date : 2024-11-01 Epub Date: 2024-07-17 DOI:10.1007/s12020-024-03955-5

Fangfang Yan, Huangdao Yu, Liping Lan, Ziqing Xu, Jinyang Zeng, Bingkun Huang, Changqin Liu, Xuejun Li, Mingzhu Lin

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引用次数: 0

摘要

目的：研究原发性醛固酮增多症（PA）患者血压（BP）在范围内的时间（TIR）与心血管综合结局之间的关系：方法：2019年1月至2021年12月期间，从厦门大学附属第一医院招募了47名PA患者。对所有首次确诊 PA 的患者进行 24 小时动态血压监测（ABPM）和心血管预后评估：结果：患者的平均年龄为（48.8 ± 11.4）岁。与没有综合心血管结果的 PA 相比，有夜间收缩压 TIR [31.2% (6.2%, 81.2%) vs. 11.5% (0.0%, 29.7%)，p = 0.02]和抗高血压药物定义日剂量 (DDDs) [2.0 (1.0, 2.8) vs. 1.0 (1.0, 2.0)，p = 0.03]的比例较低，而血糖（5.0 ± 1.0 mmol/L vs. 5.9 ± 1.5 mmol/L）较高和有饮酒史的比例较高。两组患者在年龄、性别、体重指数、吸烟、高血压持续时间、血脂水平、醛固酮增多症、门诊血压、24 小时平均血压、白天或夜间血压、夜间 SBP 或 DBP 下降百分比、24 小时血压 TIR、白天血压 TIR 或夜间 DBP TIR 方面没有差异。调整混杂因素后，在多重逻辑回归分析中，夜间收缩压TIR与心血管综合结果显著相关（调整后OR = 0.92 [95% CI 0.86, 0.99]）：结论：在 PA 患者中，夜间收缩压 TIR 与心血管综合结果有显著相关性。

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Relation between blood pressure time in range and composite cardiovascular outcomes in patients with primary aldosteronism: a retrospective case study.

Purpose: To investigate the association between blood pressure (BP) time in range (TIR) and composite cardiovascular outcomes in patients with primary aldosteronism (PA).

Methods: Between January 2019 and December 2021, 47 patients with PA were recruited from the First Affiliated Hospital of Xiamen University. Twenty-four-hour ambulatory BP monitoring (ABPM) and cardiovascular outcomes were assessed in all patients during the first diagnosis of PA.

Results: The mean age of the patients was 48.8 ± 11.4 years. Compared to PA without composite cardiovascular outcomes, the nighttime systolic BP TIR [31.2% (6.2%, 81.2%) vs. 11.5% (0.0%, 29.7%), p = 0.02] and defined daily dose (DDDs) of antihypertensive medication [2.0 (1.0, 2.8) vs. 1.0 (1.0, 2.0), p = 0.03] were lower in PA patients with composite cardiovascular outcomes, while higher glucose (5.0 ± 1.0 mmol/L vs. 5.9 ± 1.5 mmol/L) and prevalence of a history of alcohol intake was higher in PA patients with composite cardiovascular outcomes. There were no differences in age, sex, BMI, smoking, duration of hypertension, lipid levels, aldosteronism, clinic BP, 24-hour mean BP, daytime or nighttime BP, percentage of nocturnal SBP or DBP decline, 24-hour BP TIR, daytime BP TIR, or nighttime DBP TIR between the two groups. After adjusting for confounding factors, nighttime systolic BP TIR was significantly associated with composite cardiovascular outcomes (adjusted OR = 0.92 [95% CI 0.86, 0.99]) in multiple logistic regression analysis.

Conclusion: Nighttime systolic BP TIR was significantly associated with composite cardiovascular outcomes in patients with PA.

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来源期刊

Endocrine ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

5.40%

发文量

295

审稿时长

1.5 months

期刊介绍： Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.