温度感应核糖受体

IF 3.6 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
RNA Biology Pub Date : 2024-01-01 Epub Date: 2024-07-17 DOI:10.1080/15476286.2024.2379118
Savani Anbalagan
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引用次数: 0

摘要

了解细胞如何感知温度是生物学的一个基本问题,对生命进化至关重要。在许多生物体中,温度不仅能被感知,还能通过细胞过程产生。因此,人们已经通过实验阐明了各种生物体感知温度的机制。根据其他人对基于蛋白质和核酸的温度传感器的建议和论证,并利用殖民时期印度的 "punkah-wallahs "类比,我提出了细胞中每个细胞器都必须具有温度感应的理由。最后,我提出了温度感应核糖核酸受体(riboceptors),以整合所有能够感应温度并触发信号事件的 RNA 分子(mRNA、非编码 RNA 等),我将其称为温度信号传导(thermocrine signaling)。这种方法可以识别几乎所有生物体每个细胞中的核糖核酸受体,不仅可以识别温度,还可以识别其他类型的配体,包括气态溶质和水。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Temperature-sensing riboceptors.

Understanding how cells sense temperature is a fundamental question in biology and is pivotal for the evolution of life. In numerous organisms, temperature is not only sensed but also generated due to cellular processes. Consequently, the mechanisms governing temperature sensation in various organisms have been experimentally elucidated. Extending upon others' proposals and demonstration of protein- and nucleic acid-based thermosensors, and utilizing a colonial India 'punkah-wallahs' analogy, I present my rationale for the necessity of temperature sensing in every organelle in a cell. Finally, I propose temperature-sensing riboceptors (ribonucleic acid receptors) to integrate all the RNA molecules (mRNA, non-coding RNA, and so forth) capable of sensing temperature and triggering a signaling event, which I call as thermocrine signaling. This approach could enable the identification of riboceptors in every cell of almost every organism, not only for temperature but also for other classes of ligands, including gaseous solutes, and water.

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来源期刊
RNA Biology
RNA Biology 生物-生化与分子生物学
CiteScore
8.60
自引率
0.00%
发文量
82
审稿时长
1 months
期刊介绍: RNA has played a central role in all cellular processes since the beginning of life: decoding the genome, regulating gene expression, mediating molecular interactions, catalyzing chemical reactions. RNA Biology, as a leading journal in the field, provides a platform for presenting and discussing cutting-edge RNA research. RNA Biology brings together a multidisciplinary community of scientists working in the areas of: Transcription and splicing Post-transcriptional regulation of gene expression Non-coding RNAs RNA localization Translation and catalysis by RNA Structural biology Bioinformatics RNA in disease and therapy
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