生长抑素:将认知和阿尔茨海默病与治疗目标联系起来。

IF 19.3 1区 医学 Q1 PHARMACOLOGY & PHARMACY
Karin E Sandoval, Ken A Witt
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引用次数: 0

摘要

四十多年的研究证明,阿尔茨海默病(AD)与体促素(体促素释放抑制因子,SRIF)之间存在联系。SRIF 和 SRIF 表达神经元在大脑功能中发挥着至关重要的作用,可调节海马活动和记忆形成。大脑中 SRIF 和 SRIF 表达神经元的丧失是淀粉样β肽(Aβ)驱动的一系列相互依存的病理事件的中心,最终导致认知能力下降和痴呆症。SRIF 与痴呆症之间的联系进一步延伸到神经精神症状、癫痫发作活动和炎症。而临床前注意力缺失症研究表明,服用 SRIF 或 SRIF 受体激动剂能够增强认知能力。尤其是 SRIF 受体亚型-4 激活具有独特的属性,有可能缓解学习和记忆衰退,减轻合并症状,并增强大脑中 Aβ 的酶降解。在此,我们回顾了SRIF与AD之间的联系以及治疗意义。意义声明 大脑中的体生长抑素和表达体生长抑素的神经元广泛参与认知过程。在阿尔茨海默病中,体生长抑素和体生长抑素表达神经元的丧失是导致认知能力下降和痴呆的一系列相互依存的病理事件的中心。以体生长抑素介导的过程为靶点,在治疗阿尔茨海默病方面具有巨大的治疗潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Somatostatin: Linking Cognition and Alzheimer Disease to Therapeutic Targeting.

Over 4 decades of research support the link between Alzheimer disease (AD) and somatostatin [somatotropin-releasing inhibitory factor (SRIF)]. SRIF and SRIF-expressing neurons play an essential role in brain function, modulating hippocampal activity and memory formation. Loss of SRIF and SRIF-expressing neurons in the brain rests at the center of a series of interdependent pathological events driven by amyloid-β peptide (Aβ), culminating in cognitive decline and dementia. The connection between the SRIF and AD further extends to the neuropsychiatric symptoms, seizure activity, and inflammation, whereas preclinical AD investigations show SRIF or SRIF receptor agonist administration capable of enhancing cognition. SRIF receptor subtype-4 activation in particular presents unique attributes, with the potential to mitigate learning and memory decline, reduce comorbid symptoms, and enhance enzymatic degradation of Aβ in the brain. Here, we review the links between SRIF and AD along with the therapeutic implications. SIGNIFICANCE STATEMENT: Somatostatin and somatostatin-expressing neurons in the brain are extensively involved in cognition. Loss of somatostatin and somatostatin-expressing neurons in Alzheimer disease rests at the center of a series of interdependent pathological events contributing to cognitive decline and dementia. Targeting somatostatin-mediated processes has significant therapeutic potential for the treatment of Alzheimer disease.

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来源期刊
Pharmacological Reviews
Pharmacological Reviews 医学-药学
CiteScore
34.70
自引率
0.50%
发文量
40
期刊介绍: Pharmacological Reviews is a highly popular and well-received journal that has a long and rich history of success. It was first published in 1949 and is currently published bimonthly online by the American Society for Pharmacology and Experimental Therapeutics. The journal is indexed or abstracted by various databases, including Biological Abstracts, BIOSIS Previews Database, Biosciences Information Service, Current Contents/Life Sciences, EMBASE/Excerpta Medica, Index Medicus, Index to Scientific Reviews, Medical Documentation Service, Reference Update, Research Alerts, Science Citation Index, and SciSearch. Pharmacological Reviews offers comprehensive reviews of new pharmacological fields and is able to stay up-to-date with published content. Overall, it is highly regarded by scholars.
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