IGF-1 可诱导鸣禽发生性别特异性氧化损伤和死亡。

IF 2.3 2区 环境科学与生态学 Q2 ECOLOGY
Oecologia Pub Date : 2024-08-01 Epub Date: 2024-07-16 DOI:10.1007/s00442-024-05587-y
Ádám Z Lendvai, Zsófia Tóth, Katharina Mahr, Janka Pénzes, Sarah Vogel-Kindgen, Bruno A Gander, Csongor I Vágási
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引用次数: 0

摘要

胰岛素样生长因子 1(IGF-1)是一种调节基本生命史特征的多效激素,因其在决定个体衰老过程中的重要作用而闻名。高水平的 IGF-1 与死亡率增加有关,并被认为会导致氧化应激。这种效应已在实验室动物身上观察到,但是否与野生脊椎动物有关还没有进行过测试。这令人惊讶,因为研究个体寿命差异的形成机制对于了解自由生活动物种群的死亡模式非常重要。我们在半自然条件下模拟了人工饲养的胡芦苇(一种生活节奏特别快的鸣禽)体内 IGF-1 水平的升高,从而验证了这一假设。我们通过皮下注射装有 IGF-1 的缓释生物可降解微球,在至少 24 小时内实现了激素在自然范围内 3.7 倍的系统性增长。脂质氧化损伤显示出明显的性别差异:雄鸟在处理后第二天的氧化损伤显著增加,并在处理后四天恢复到基线水平,而雌鸟则没有明显的处理效果。虽然治疗组之间的存活率总体上没有差异,但初始(治疗前)IGF-1水平高和治疗后血浆丙二醛水平低与雄性存活率提高有关。这些结果表明,雄性可能比雌性更容易受到 IGF-1 诱导的氧化应激的影响,而迅速恢复氧化平衡可能与体能有关。IGF-1水平是在对立的选择力量下进化的,这种激素水平的自然变化可能反映了个体优化的结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

IGF-1 induces sex-specific oxidative damage and mortality in a songbird.

IGF-1 induces sex-specific oxidative damage and mortality in a songbird.

The insulin-like growth factor 1 (IGF-1) is a pleiotropic hormone that regulates essential life-history traits and is known for its major contribution to determining individual ageing processes. High levels of IGF-1 have been linked to increased mortality and are hypothesised to cause oxidative stress. This effect has been observed in laboratory animals, but whether it pertains to wild vertebrates has not been tested. This is surprising because studying the mechanisms that shape individual differences in lifespan is important to understanding mortality patterns in populations of free-living animals. We tested this hypothesis under semi-natural conditions by simulating elevated IGF-1 levels in captive bearded reedlings, a songbird species with an exceptionally fast pace of life. We subcutaneously injected slow-release biodegradable microspheres loaded with IGF-1 and achieved a systemic 3.7-fold increase of the hormone within the natural range for at least 24 h. Oxidative damage to lipids showed marked sexual differences: it significantly increased the day after the manipulation in treated males and returned to baseline levels four days post-treatment, while no treatment effect was apparent in females. Although there was no overall difference in survival between the treatment groups, high initial (pre-treatment) IGF-1 and low post-treatment plasma malondialdehyde levels were associated with enhanced survival prospects in males. These results suggest that males may be more susceptible to IGF-1-induced oxidative stress than females and quickly restoring oxidative balance may be related to fitness. IGF-1 levels evolve under opposing selection forces, and natural variation in this hormone's level may reflect the outcome of individual optimization.

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来源期刊
Oecologia
Oecologia 环境科学-生态学
CiteScore
5.10
自引率
0.00%
发文量
192
审稿时长
5.3 months
期刊介绍: Oecologia publishes innovative ecological research of international interest. We seek reviews, advances in methodology, and original contributions, emphasizing the following areas: Population ecology, Plant-microbe-animal interactions, Ecosystem ecology, Community ecology, Global change ecology, Conservation ecology, Behavioral ecology and Physiological Ecology. In general, studies that are purely descriptive, mathematical, documentary, and/or natural history will not be considered.
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