Nathaniel J Helwig, Laura E Schwager, Alexander C Berry, Anna C Zucker, Jacob S Venenga, Samantha C Sterbenz, Nathaniel D M Jenkins
{"title":"豚草叶提取物对情绪、认知和运动认知能力以及血压、心率和心室复极化的急性剂量反应效应。","authors":"Nathaniel J Helwig, Laura E Schwager, Alexander C Berry, Anna C Zucker, Jacob S Venenga, Samantha C Sterbenz, Nathaniel D M Jenkins","doi":"10.1080/15502783.2024.2379424","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>We conducted a randomized, double-blind, placebo-controlled crossover trial in young adults to examine the dose-dependent (600 mg versus 1200 mg), acute effects of consumption of an <i>Ilex guayusa</i> tea extract (GLE) on mood, cognitive and motor-cognitive performance, as well as its acute cardiovascular effects.</p><p><strong>Methods: </strong>Twenty-five adults (mean ± SD, age = 28 ± 7 y; 9 M/16 F) completed familiarization and then three randomly ordered experimental visits where they consumed either 600 mg (GLE<sub>600</sub>) or 1200 mg (GLE<sub>1200</sub>) GLE or placebo (PLA). Following supplement consumption, participants completed a mood state survey, assessments of perceived jitteriness, energy, and focus, and neurocognitive and motor-cognitive testing. Blood pressure (BP), heart rate, and QT interval length were determined before and after supplementation.</p><p><strong>Results: </strong>GLE<sub>600</sub> significantly improved total mood disturbance (mean ± SE difference = -6.9 ± 2.6 au, <i>p</i> = 0.034), fatigue-inertia (-2.84 ± 0.89 au, <i>p</i> = 0.008), perceived energy (+13.00 ± 4.49 au; <i>p</i> = 0.02), motor speed (+4.52 ± 1.42 au, <i>p</i> = 0.008), and psychomotor speed (+7.20 ± 2.16 au, <i>p</i> = 0.005) relative to PLA. GLE<sub>1200</sub> also improved psychomotor speed (+5.08 ± 2.16 ms, <i>p</i> = 0.045) and uniquely increased motor-cognitive performance as reflected by a decrease in reaction time (-0.106 ± 0.04 ms, <i>p</i> = 0.026) during a neurocognitive hop test. The effect of GLE on jitteriness was both dose- and sex-dependent. Jitteriness increased with increasing GLE dose in women only (<i>p</i> < 0.001). Both GLE<sub>600</sub> and GLE<sub>1200</sub> similarly increased systolic and diastolic BP by 4-5 mmHg (<i>p</i> ≤ 0.022). Neither GLE<sub>600</sub> nor GLE<sub>1200</sub> acutely influenced QTc length (<i>p</i> = 0.31).</p><p><strong>Conclusions: </strong>The goal of GLE supplementation should be considered when selecting a dosing strategy. Lower dosages of GLE (e.g. 600 mg) appear to optimize cognitive and mood-related outcomes while limiting side-effects such as jitteriness in women, and higher dosages may be necessary (e.g. 1200 mg) to promote improvements in motor-cognitive performance.</p>","PeriodicalId":17400,"journal":{"name":"Journal of the International Society of Sports Nutrition","volume":"21 1","pages":"2379424"},"PeriodicalIF":4.5000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11257001/pdf/","citationCount":"0","resultStr":"{\"title\":\"Acute, dose-response effects of guayusa leaf extract on mood, cognitive and motor-cognitive performance, and blood pressure, heart rate, and ventricular repolarization.\",\"authors\":\"Nathaniel J Helwig, Laura E Schwager, Alexander C Berry, Anna C Zucker, Jacob S Venenga, Samantha C Sterbenz, Nathaniel D M Jenkins\",\"doi\":\"10.1080/15502783.2024.2379424\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>We conducted a randomized, double-blind, placebo-controlled crossover trial in young adults to examine the dose-dependent (600 mg versus 1200 mg), acute effects of consumption of an <i>Ilex guayusa</i> tea extract (GLE) on mood, cognitive and motor-cognitive performance, as well as its acute cardiovascular effects.</p><p><strong>Methods: </strong>Twenty-five adults (mean ± SD, age = 28 ± 7 y; 9 M/16 F) completed familiarization and then three randomly ordered experimental visits where they consumed either 600 mg (GLE<sub>600</sub>) or 1200 mg (GLE<sub>1200</sub>) GLE or placebo (PLA). Following supplement consumption, participants completed a mood state survey, assessments of perceived jitteriness, energy, and focus, and neurocognitive and motor-cognitive testing. Blood pressure (BP), heart rate, and QT interval length were determined before and after supplementation.</p><p><strong>Results: </strong>GLE<sub>600</sub> significantly improved total mood disturbance (mean ± SE difference = -6.9 ± 2.6 au, <i>p</i> = 0.034), fatigue-inertia (-2.84 ± 0.89 au, <i>p</i> = 0.008), perceived energy (+13.00 ± 4.49 au; <i>p</i> = 0.02), motor speed (+4.52 ± 1.42 au, <i>p</i> = 0.008), and psychomotor speed (+7.20 ± 2.16 au, <i>p</i> = 0.005) relative to PLA. GLE<sub>1200</sub> also improved psychomotor speed (+5.08 ± 2.16 ms, <i>p</i> = 0.045) and uniquely increased motor-cognitive performance as reflected by a decrease in reaction time (-0.106 ± 0.04 ms, <i>p</i> = 0.026) during a neurocognitive hop test. The effect of GLE on jitteriness was both dose- and sex-dependent. Jitteriness increased with increasing GLE dose in women only (<i>p</i> < 0.001). Both GLE<sub>600</sub> and GLE<sub>1200</sub> similarly increased systolic and diastolic BP by 4-5 mmHg (<i>p</i> ≤ 0.022). Neither GLE<sub>600</sub> nor GLE<sub>1200</sub> acutely influenced QTc length (<i>p</i> = 0.31).</p><p><strong>Conclusions: </strong>The goal of GLE supplementation should be considered when selecting a dosing strategy. Lower dosages of GLE (e.g. 600 mg) appear to optimize cognitive and mood-related outcomes while limiting side-effects such as jitteriness in women, and higher dosages may be necessary (e.g. 1200 mg) to promote improvements in motor-cognitive performance.</p>\",\"PeriodicalId\":17400,\"journal\":{\"name\":\"Journal of the International Society of Sports Nutrition\",\"volume\":\"21 1\",\"pages\":\"2379424\"},\"PeriodicalIF\":4.5000,\"publicationDate\":\"2024-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11257001/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the International Society of Sports Nutrition\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/15502783.2024.2379424\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/7/16 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the International Society of Sports Nutrition","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/15502783.2024.2379424","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/16 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
Acute, dose-response effects of guayusa leaf extract on mood, cognitive and motor-cognitive performance, and blood pressure, heart rate, and ventricular repolarization.
Purpose: We conducted a randomized, double-blind, placebo-controlled crossover trial in young adults to examine the dose-dependent (600 mg versus 1200 mg), acute effects of consumption of an Ilex guayusa tea extract (GLE) on mood, cognitive and motor-cognitive performance, as well as its acute cardiovascular effects.
Methods: Twenty-five adults (mean ± SD, age = 28 ± 7 y; 9 M/16 F) completed familiarization and then three randomly ordered experimental visits where they consumed either 600 mg (GLE600) or 1200 mg (GLE1200) GLE or placebo (PLA). Following supplement consumption, participants completed a mood state survey, assessments of perceived jitteriness, energy, and focus, and neurocognitive and motor-cognitive testing. Blood pressure (BP), heart rate, and QT interval length were determined before and after supplementation.
Results: GLE600 significantly improved total mood disturbance (mean ± SE difference = -6.9 ± 2.6 au, p = 0.034), fatigue-inertia (-2.84 ± 0.89 au, p = 0.008), perceived energy (+13.00 ± 4.49 au; p = 0.02), motor speed (+4.52 ± 1.42 au, p = 0.008), and psychomotor speed (+7.20 ± 2.16 au, p = 0.005) relative to PLA. GLE1200 also improved psychomotor speed (+5.08 ± 2.16 ms, p = 0.045) and uniquely increased motor-cognitive performance as reflected by a decrease in reaction time (-0.106 ± 0.04 ms, p = 0.026) during a neurocognitive hop test. The effect of GLE on jitteriness was both dose- and sex-dependent. Jitteriness increased with increasing GLE dose in women only (p < 0.001). Both GLE600 and GLE1200 similarly increased systolic and diastolic BP by 4-5 mmHg (p ≤ 0.022). Neither GLE600 nor GLE1200 acutely influenced QTc length (p = 0.31).
Conclusions: The goal of GLE supplementation should be considered when selecting a dosing strategy. Lower dosages of GLE (e.g. 600 mg) appear to optimize cognitive and mood-related outcomes while limiting side-effects such as jitteriness in women, and higher dosages may be necessary (e.g. 1200 mg) to promote improvements in motor-cognitive performance.
期刊介绍:
Journal of the International Society of Sports Nutrition (JISSN) focuses on the acute and chronic effects of sports nutrition and supplementation strategies on body composition, physical performance and metabolism. JISSN is aimed at researchers and sport enthusiasts focused on delivering knowledge on exercise and nutrition on health, disease, rehabilitation, training, and performance. The journal provides a platform on which readers can determine nutritional strategies that may enhance exercise and/or training adaptations leading to improved health and performance.